Registration Dossier
Registration Dossier
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EC number: 606-740-6 | CAS number: 21331-43-1
Vapour pressure
Administrative data
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Study started 2012-01-25. Test phase 2012-02-07 to 2012-04-04. Report complete 2012-05-11.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Meets the criteria for classification as reliable without restriction according to Klimisch et al (1997).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- gas saturation method
Test material
- Reference substance name:
- 4-(naphthalen-2-yl)-1,3-thiazol-2-amine
- EC Number:
- 606-740-6
- Cas Number:
- 21331-43-1
- Molecular formula:
- C13H10N2S
- IUPAC Name:
- 4-(naphthalen-2-yl)-1,3-thiazol-2-amine
Constituent 1
Results and discussion
Vapour pressure
- Temp.:
- 25 °C
- Vapour pressure:
- < 0 Pa
- Remarks on result:
- other: Based on theoretical calculation
Any other information on results incl. tables
The test substance was analysed for vapour pressure at 25 deg. C using a gas saturation aparatus. the analyte quantification was carried out after gas saturation by HPLC.
No analyte was observed in the test solutions therefore direct measurement of vapour pressure using the gas saturation method was not possible. The vapour pressure was determined using a theoretical calculation based on the LOQ of the quantitative HPLC method.
No evaluation of vapour presssure at 20 deg. C using this method was undertaken as the results would not be significantly different and would be lower than those obtained at 25 deg. C.
Applicant's summary and conclusion
- Conclusions:
- The vapour pressure at 25 deg. C was determined to be <3.05 x 10-6 Pa based on a theoretical calculation.
- Executive summary:
Introduction
The study was undertaken to determine the vapur pressure of the test material. The test method used was compatible with EU Method A.4 (Vapour Pressure), however, vapur pressure was determined using a theoretical calculation as no analyte was observed in the test solutions.
Results & Conclusions
The vapour pressure at 25 deg. C was determined to be <3.05 x 10-6 Pa based on a theoretical calculation.
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