Registration Dossier
Registration Dossier
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EC number: 814-084-9 | CAS number: 38129-46-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- september 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- methyl 3-[(3-methoxy-3-oxopropyl)(2-phenylethyl)amino]propanoate
- EC Number:
- 814-084-9
- Cas Number:
- 38129-46-3
- Molecular formula:
- C16 H23 N O4
- IUPAC Name:
- methyl 3-[(3-methoxy-3-oxopropyl)(2-phenylethyl)amino]propanoate
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Batch OP 3/88
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 2000mg/kg
- No. of animals per sex per dose:
- 10 animals : 5 males/ 5 females
- Control animals:
- yes
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat. (total fraction)
- Mortality:
- No mortality observed
- Clinical signs:
- other: No sign of toxicity observed
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under experimental conditions, LD 50 of 428 DIESTER by oral route in rats is > 2000mg/kg. No sign of toxicity was observed.
- Executive summary:
Under experimental conditions, LD 50 of 428 DIESTER by oral route in rats is > 2000mg/kg. No sign of toxicity was observed.
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