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EC number: 204-889-8 | CAS number: 128-49-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
No data are available for the registered substance, however data are available for the corresponding sodium salt of the substance, docusate sodium (CAS 577-11-7). These data are used for read-across to the registered substance calcium docusate (CAS 128 -49 -4). The presence of either of the counterions sodium or calcium is not considered to have an impact on the toxicity. It is therefore considered justified to use the data of the sodium salt for read across to the calcium salt of docusate.
Additional information
The environmental hazard assessment for (fresh-) water organisms and sediment habitats is supported by several acute studies (pelagic compartment), a chronic Daphnia reproduction study and by using scientific argumentation (sediment dwelling organisms). The data and conclusions summarised in this section for docusate sodium are considered to be valid for the registered substance (docusate calcium).
For the environmental hazard assessment of Docusate calcium acute toxicity studies for the read-across analogue docusate sodium are available for freshwater fish, daphnids, freshwater algae and STP microorganisms. In addition, a long-term Daphnia reproduction study is available. A long-term study for fish is waived since a longtern study is available for the more sensitive group, e.g., the daphinds. Experimental information about toxicity on marine organisms is not available.
Some of the above studies were conducted with test materials which contained the submission substance at > 80%. The majority of the acute aquatic studies, however, was performed with Docusate Sodium containing formulations. These test materials contained typically between 64 and 70 % Docusate Sodium. For the assessment of all available studies it was assumed that neither synergistic nor antagonistic effects influence the toxicity of Docusate Sodium and - as worst case scenario - the toxicity observed for the test material is only due to the toxicity of Docusate Sodium. The concentration of Docusate Sodium in the respective test materials was used to calculate the effect concentrations for Docusate Sodium.
The short-term EC50/LC50 values for fish, Daphnia, algae and microorganisms were 49, 15.2, 82.5 and 164 mg Docusate Sodium/L, respectively. The EC10 (mortality) obtained in a 21 day chronic daphina reproduction study was 9.0 mg/L. The reproduction of Daphnia was not affected at concentrations up to 11 mg/L, a concentration at which mortality was relevant.
Docusate calcium is expected to be ready biodegradable and (despite the QSAR predictions) is expected to have a low log Koc resulting in a low likelihood to partition to sediment and is only moderately toxic to pelagic aquatic organisms. Therefore, Docusate Calcium is not expected to cause adverse effects on sediment organisms. Consequently sediment toxicity tests do not need to be conducted to assess the risk for sediment-dwelling organisms.
The daphnids were the most sensitive trophic level with an geometric mean EC50 of 15.2 mg Docusate Sodium/L and an 21 day-EC10 (mortality) of 9.0 mg/L. This value of 9.0 mg/L will be used as worst case scenario for the risk assessment of aquatic organisms exposed to docusate calcium.
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