2-fluorobenzoyl chloride

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Report date:

1999

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method C.2 (Acute Toxicity for Daphnia)

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

2-fluorobenzoyl chloride

EC Number:

206-887-2

EC Name:

2-fluorobenzoyl chloride

Cas Number:

393-52-2

Molecular formula:

C7H4ClFO

IUPAC Name:

2-fluorobenzoyl chloride

Specific details on test material used for the study:

2-Fluorobenzoyl-Chloride / 393-52-2 / 206-87-2

Test solutions

Vehicle:

yes

Details on test solutions:

In the pre-experiment to the solubility of the test item, its half-life in test water was determined to be less than 1.5 hours. After 20 hours, the substance has been converted to the corrisponding 2-Fluorobenzoic Acid. Therfore, according to international recommendations for substances with a hal-life less than 4 hours, the breakdown product of the parent substance was tested for its toxicity.

Test organisms

Test organisms (species):

Daphnia magna

Details on test organisms:

Young daphnids (6-24 hours old) bred in the laboratories under identical temperature and light conditions as in the tests. The cultivation is performed in reconstituted water of identical quality as the water used in the tests.

Study design

Test type:

static

Water media type:

freshwater

Limit test:

yes

Total exposure duration:

48 h

Test conditions

Hardness:

250 mg/l

Test temperature:

room temperature

pH:

3.3 after the 24-hour stirring period; adjusted to 8.0 with 1M NaOH

Dissolved oxygen:

At the start and and the end of the tests the oxygen concentrations were at least 8.2 mg/l.

Nominal and measured concentrations:

nominal concentration 100 mg/l

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

48 h

Dose descriptor:

LC50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Effect concentrations 2

Duration:

48 h

Dose descriptor:

NOEC

Effect conc.:

>= 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Details on results:

The degradation product of the test item has no toxic effect on the daphnids up to a nominal concentration of 100 mg/l. After the 24-hr stirring period the mean concentration of FBA in the test medium corresponded to a FBC concentration of 99 mg/l, demonstrating the complete transformation of the test item to its breakdown product within the 24-hr stirring period. At the end of the test the FBA concentration corresponded to 84 mg FBC/l. Based on the measured concentration of FBA at the start and the end of the incubation period the concentrations ranged from 99 to 84% of the nominal concentration. The resuls are based on the nominal concentrations.

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

It was shown that the breakdown product of 2-fluoro benzoyl chloride has no toxic effect on daphnids up to a concentration of nominal 100 mg FBC/l.