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Diss Factsheets
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EC number: 948-047-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 5 June 1991 - 8 June 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Ethylene distearate
- EC Number:
- 211-014-3
- EC Name:
- Ethylene distearate
- Cas Number:
- 627-83-8
- Molecular formula:
- C38H74O4
- IUPAC Name:
- ethane-1,2-diyl dioctadecanoate
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.1g
- Duration of treatment / exposure:
- Following instillation the animals were returned to their respective cages for 24 hours. The eyes were not washed out following instillation.
- Observation period (in vivo):
- Ocular lesions were evluated 24, 48 and 72 hours post-administration.
- Number of animals or in vitro replicates:
- 3 Males and 3 females.
Results and discussion
In vivo
Results
- Irritation parameter:
- maximum mean total score (MMTS)
- Time point:
- 24 h
- Score:
- 3
- Reversibility:
- other: Partially reversible within 72 hours
- Remarks on result:
- probability of mild irritation
- Other effects:
- All animals appeared active and healthy. Apart from the eye irritation noted, there were no signs of gross toxicity, adverse pharmacological effects or abnormal behaviour. No corneal opacity or iritis was observed during th study.Conjunctival irritation was evident in all treated eyes at 24 hours post-instillation. By 72 hours all but 2 animals were free of irritation.
Any other information on results incl. tables
Incidence of Irritation
Corneal Opacity | Iritis | Conjunctival Irritation | |
24 hours | 0/6 | 0/6 | 6/6 |
48 hours | 0/6 | 0/6 | 4/6 |
72 hours | 0/6 | 0/6 | 2/6 |
Severity of Irritation
Maximum Mean Irritation Score | |
24 hours | 3 (minimally irritating) |
48 hours | 1.3 (practically non-irritating) |
72 hours | 0.7 (practically non-irritating) |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the scoring system used in this study the substance is considered to be minimally irritating to eyes.
- Executive summary:
The irritant or corrosive of a single dose of the substance into the eyes of New Zealand White rabbits (3/sex) was investigated in this in vivo study. One eye of each rabbit was instilled with 0.1g of the test substance and irritation was scored at 24, 48 and 72 hours administration. All animals appeared active and healthy. Apart from the eye irritation noted, there were no signs of gross toxicity, adverse pharmacological effects or abnormal behaviour. No corneal opacity or iritis was observed during th study.Conjunctival irritation was evident in all treated eyes at 24 hours post-instillation. By 72 hours all but 2 animals were free of irritation. The 24 hour Maximum Mean Total Score was 3 and based on this score the substance is considered to be minimally irritating to eyes.
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