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Diss Factsheets
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EC number: 928-806-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- the study does not need to be conducted because the substance is highly insoluble in water
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): T002615
- Appearance: solid white
- Analytical purity: > 98 %
- Lot/batch No.: 00403487
- Expiration date of the lot/batch: 31 December 2003
- Storage condition of test material: at room temperature at about 20°C - Radiolabelling:
- no
- Buffers:
- - pH: 4, 7, 9
- Type and final molarity of buffer: buffer pH 4 biphthalate, buffer pH 7 phosphate, buffer pH 9 borate, no final molarity reported
- Composition of buffer: no data - Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: glass flasks which were stoppered or sealed with an inert material
- Measures to exclude oxygen: Nitrogen was passed through the buffer solutions for 2 minutes except when freshly sterilized.
TEST MEDIUM
- Volume used/treatment: 50 mL
- Preparation of test medium:
The solubility of T002615 in the buffer solutions pH 4, 7, 9 is very low, therefore a test with different solubilizers was performed to increase the solubility of T002615.
Preparation of the test solutions with DMF as solubilizer:
13.97 mg, 12.22 mg and 12.24 mg of T002615 were each dissolved in 2 mL DMF and filled up to 100 mL with the respective buffer solution (pH 4, 7, 9).
Preparation of the test solutions with acetonitrile as solubilizer:
14.50 mg, 12.03 mg and 12.82 mg of T002615 were each dissolved in 2 mL acetonitrile and filled up to 100 mL with the respective buffer solution (pH 4, 7, 9).
Preparation of the test solutions with DMSO as solubilizer:
12.28 mg, 12.29 mg and 12.59 mg of T002615 were each dissolved in 2 mL DMSO and filled up to 100 mL with the respective buffer solution (pH 4, 7, 9).
Preparation of the test solutions with THF as solubilizer:
12.92 mg, 12.80 mg and 14.09 mg of T002615 were each dissolved in 2 mL THF and filled up to 100 mL with the respective buffer solution (pH 4, 7, 9).
These solutions were ultrasonificated for 10 minutes. To obtain test solutions of not more than half the water solubility, the solutions were diluted 1:1 with the respective buffer. Two aliquots of each test solution of approximately 50 mL each were transferred into 50 mL Erlenmeyer flasks in order to perform duplicate tests. - Details on results:
- The test item was dissolved in the buffer solutions at pH 4, 7 and 9. The concentration of the test item was determined as a function of time at each pH. The solubility of T002615 in the buffer solutions pH 4, 7 and 9 was very low. It was not possible to increase the solubility of the test item with the use of different solubilizers (DMF, acetonitrile, DMSO and THF). Peaks obtained, if any, were too small to follow a degradation curve or even to allow quantification.
- Conclusions:
- The solubility of T002615 in the buffer solutions pH 4, 7 and 9 was very low. It was not possible to increase the solubility of the test item with the use of different solubilizers (DMF, acetonitrile, DMSO and THF). Peaks obtained, if any, were too small to follow a degradation curve or even to allow quantification. According to the EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH), the method is applicable only to water soluble substances. The test item shows no significant solubility in the different solvent systems. Therefore, no further testing could be performed with T002615 at pH 4, 7 and 9.
Reference
Description of key information
Based on the guideline study (Tognucci, 2003) it is concluded that a hydrolysis study for the test item (T002615) cannot be performed. The solubility of T002615 in the buffer solutions pH 4, 7 and 9 was very low. It was not possible to increase the solubility of the test item with the use of different solubilizers (DMF, acetonitrile, DMSO and THF). Peaks obtained, if any, were too small to follow a degradation curve or even to allow quantification. According to the EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH), the method is applicable only to water soluble substances. The test item shows no significant solubility in the different solvent systems. Therefore, no further testing could be performed with T002615 at pH 4, 7 and 9.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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