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EC number: 946-420-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to microorganisms, other
- Remarks:
- ready biodegradation test including toxicity control
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Version / remarks:
- 1997; including toxicity control
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): Activated sludge from the aeration basin of a municipal sweage treatment plant (Moers, Germany)
- Storage length: 1 day
- Preparation of inoculum for exposure: After determination of the suspended solids dry weight 1875 mg suspended solids was filtered by means of a water jet pump through a filter paper (Whatman GmbH, black ribbon 589(1)). The sludge was washed twice with mineral medium. Afterwards, it was suspended in 250 mL mineral medium and stirred until it was homogeneous. 4 mL of this suspension were used to inoculate 1 L of mineral medium.
- Concentration of sludge: 30 mg/L suspended solids - Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 28 d
- Details on test conditions:
- TEST CONDITIONS
- Test temperature: 22 ± 1°C
- pH: 7.4
- pH adjusted: yes, if needed
- Suspended solids concentration: 30 mg/L
- Continuous darkness: yes
TEST SYSTEM
- Number of culture flasks/concentration: 3 x blank control, 2 x Abiotic control, 2 x Reference substance, 3 x Test substance, 2 x Toxicity control
- Measuring equipment: Digital Respirometer System, Sensomat system, Liebherr, Aqualytic, Langen, Germany
- Test performed in closed vessels due to significant volatility of test substance: closed system due to the parameter measured (oxygen consumption)
- Test performed in open system: no
- Details of trap for CO2 and volatile organics if used: trapped by sodium hydroxide
- Other: As inhibitor of nitrogen oxidation 15 drops of N-allylthiourea were added to each test vessel.
CONTROL AND BLANK SYSTEM
- Inoculum blank: 3 vessels
- Abiotic sterile control: 2 vessels
- Toxicity control: 2 vessels - Reference substance (positive control):
- no
- Duration:
- 14 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- inhibition of total respiration
- Conclusions:
- The substance was not inhibitory to microorganisms at 100 mg/L (75% degradation in the toxicity control after 14 d).
- Executive summary:
Polyglycerin caprylate/caprinatewas tested in a manometric respirometry test according to the OECD Guideline for Testing of Chemicals, No. 301 F, for 28 days to determine whether the test substance is readily biodegradable.
The oxygen uptake by a stirred preparation of the test substance in a concentration of 100 mg/L in a mineral medium, inoculated with unadapted microorganisms, was measured automatically over a period of 28 days in a darkened, enclosed respirometer at 22 ± 1°C. Biodegradation is expressed as percentage oxygen uptake (corrected for blank uptake) of the Theoretical Oxygen Demand (ThODNH4) calculated for the test substance.
Activated sludge from a municipal sewage treatment plant (Moers, Germany) was used as inoculum. As reference substance (procedure control) sodium benzoate in a concentration of 100 mg/L was
used. After 14 days the reference substance was sufficiently degraded to 89 % of the ThODNH4, thus confirming the suitability of the used activated sludge inoculum and fulfilling the validity criteria
mentioned in the relevant test guideline. The reference substance was degraded to 93 % of the ThODNH4 after 28 days.
At the end of the exposure period a degradation rate of 86 % of the ThODNH4 of the test substance was measured. 62 % was the degradation rate at the end of the 10-days window.
The test substance showed no toxicity towards microorganisms of the activated sludge because 75 % degradation (based on ThOD) was recorded within 14 days in the toxicity control preparations containing both the test substance and the positive control substance in the same concentrations.
Reference
Description of key information
14 d NOAEC = 10 mg/L (OECD TG 301 F; RL1; GLP)
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 100 mg/L
Additional information
Polyglycerin caprylate/caprinatewas tested in a manometric respirometry test according to the OECD Guideline for Testing of Chemicals, No. 301 F, for 28 days to determine whether the test substance is readily biodegradable.
The oxygen uptake by a stirred preparation of the test substance in a concentration of 100 mg/L in a mineral medium, inoculated with unadapted microorganisms, was measured automatically over a period of 28 days in a darkened, enclosed respirometer at 22 ± 1°C. Biodegradation is expressed as percentage oxygen uptake (corrected for blank uptake) of the Theoretical Oxygen Demand (ThODNH4) calculated for the test substance.
Activated sludge from a municipal sewage treatment plant (Moers, Germany) was used as inoculum. As reference substance (procedure control) sodium benzoate in a concentration of 100 mg/L was
used. After 14 days the reference substance was sufficiently degraded to 89 % of the ThODNH4, thus confirming the suitability of the used activated sludge inoculum and fulfilling the validity criteria
mentioned in the relevant test guideline. The reference substance was degraded to 93 % of the ThODNH4 after 28 days.
At the end of the exposure period a degradation rate of 86 % of the ThODNH4 of the test substance was measured. 62 % was the degradation rate at the end of the 10-days window.
The test substance showed no toxicity towards microorganisms of the activated sludge because 75 % degradation (based on ThOD) was recorded within 14 days in the toxicity control preparations containing both the test substance and the positive control substance in the same concentrations.
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