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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
short-term repeated dose toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
abstract

Data source

Reference
Reference Type:
publication
Title:
The toxicity of gallic acid, pyrogallol, tannic acid, and Quercus havardi in the rabbit
Author:
Dollahite, J.W.; Pigeon, R.F.; Camp, B.J.
Year:
1962
Bibliographic source:
American Journal of Veterinary Research. 23: 1264-1267

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
- Principle of test: a repeated dose test was performed to rabbit
- Short description of test conditions: no data
- Parameters analysed / observed: mortality and effects related to administration of the substance
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Pyrogallol
EC Number:
201-762-9
EC Name:
Pyrogallol
Cas Number:
87-66-1
Molecular formula:
C6H6O3
IUPAC Name:
benzene-1,2,3-triol
impurity 1
Reference substance name:
unknown impurities
IUPAC Name:
unknown impurities
Test material form:
not specified
Details on test material:
not specified
Specific details on test material used for the study:
no data

Test animals

Species:
rabbit
Strain:
not specified
Details on species / strain selection:
no data
Sex:
not specified
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Route of administration:
oral: gavage
Details on route of administration:
no data
Vehicle:
not specified
Details on oral exposure:
no data
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
10-day exposure
Frequency of treatment:
no data
Doses / concentrationsopen allclose all
Dose / conc.:
500 mg/kg bw/day (nominal)
Dose / conc.:
1 000 mg/kg bw/day (nominal)
No. of animals per sex per dose:
total of animals tested: 6
Sex: n.p.
Control animals:
not specified
Details on study design:
observation period n.p.
Positive control:
no data

Results and discussion

Effect levels

Key result
Dose descriptor:
other: repeated-dose LD50
Effect level:
700 mg/kg bw/day (nominal)
Based on:
test mat.
Sex:
not specified
Basis for effect level:
mortality

Any other information on results incl. tables

A repeated-dose LD50 of 700 mg/kg/day was determined. The following symptoms were observed in some treated rabbits: congestion of the lung; congestion of the liver, with prominent lobules (alternate light and congested areas were observed); congestion and swelling of the kidneys; congestion and enlargement of the spleen; and gastritis, usually with hemorrhages and/or ulcers. A smooth white exudate was induced on the gastric mucosa and there was a varying degree of enteritis in the duodenum and cecum. The doses which caused these effects and the number of animals affected were n.p.

Applicant's summary and conclusion

Conclusions:
In rabbits, a multiple oral dose (LD50) of pyrogallol is 0.7 g/kg per day when administered daily for ten days.