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Diss Factsheets
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EC number: 614-598-1 | CAS number: 68553-12-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Study conducted 24 November to 23 December 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-D (Determination of the "Ready" Biodegradability - Manometric Respirometry Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: RL 686/15
- Expiration date of the lot/batch: 30 October 2018
- Purity test date: Complex mixture
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Room temperature
- Stability under test conditions: No data
- Solubility and stability of the test substance in the solvent/vehicle: Low solubility in aqueous media
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: No data - Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): Worlingworth sewage treatment works, Suffolk, UK
- Storage conditions: aerated
- Storage length: No data
- Pretreatment: No
- Concentration of sludge: 30 mg/L - Duration of test (contact time):
- <= 28 d
- Initial conc.:
- <= 50 mg/L
- Based on:
- test mat.
- Remarks:
- Test item solvent stock solution prepared by dissolving test item in tetrahydrofuran (THF), followed by dilution in acetone. An aliquot added to test vessels
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
- Composition of medium:
- Additional substrate:
- Solubilising agent (type and concentration if used):
- Test temperature:
- pH:
- pH adjusted: yes/no
- CEC (meq/100 g):
- Aeration of dilution water:
- Suspended solids concentration:
- Continuous darkness: yes/no
- Other:
TEST SYSTEM
- Culturing apparatus:
- Number of culture flasks/concentration:
- Method used to create aerobic conditions:
- Method used to create anaerobic conditions:
- Measuring equipment:
- Test performed in closed vessels due to significant volatility of test substance:
- Test performed in open system:
- Details of trap for CO2 and volatile organics if used:
- Other:
SAMPLING
- Sampling frequency:
- Sampling method:
- Sterility check if applicable:
- Sample storage before analysis:
- Other:
CONTROL AND BLANK SYSTEM
- Inoculum blank:
- Abiotic sterile control:
- Toxicity control:
- Other:
STATISTICAL METHODS: - Key result
- Parameter:
- % degradation (CO2 evolution)
- Value:
- >= 63
- Sampling time:
- 28 d
- Details on results:
- The test item can be classed as a substance of unknown or variable composition, therefore, under EC regulation 286/2011 the 60% pass level can be determined after 28 days and the 10-day window pass level can be waived. The test item showed 63% biodegradation at the end of the test (Day 28) and may be considered readily biodegradable under the conditions of the test.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The test item can be classed as a substance of unknown or variable composition, therefore, under EC regulation 286/2011 the 60% pass level can be determined after 28 days and the 10-day window pass level can be waived. The test item showed 63% biodegradation at the end of the test (Day 28) and may be considered readily biodegradable under the conditions of the test. The reference item attained 83% biodegradation after 14 days and 86% biodegradation after 28 days confirming that sewage sludge inoculum was responding normally. The toxicity control attained 88% biodegradation after 14 days and 89% biodegradation after 28 days indicating the test item was not toxic to the sewage treatment micro-organisms used in the test.
- Executive summary:
A study was performed to determine the ready biodegradabilty of the test item when exposed to sewage treatment micro-organisms under aerobic conditions. The test was conducted according to the principles of GLP and followed internationally accepted test guidelines.
Sewage sludge was exposed to an aqueous dispersion of the test item at the nominal test concentration of 50 mg/L over a period of 28 days. The respiration rate (CO2 evolution) was measured daily throughout the test period and the % biodegradation calculated. The test validity criteria were met and the study is therefore acceptable. The reference item attained 83% biodegradation after 14 days indicating the test inoculum was responding normally. The toxicity control attained 88% biodegradation after 14 days indicating the test item was not toxic to the sewage treatment micro-organisms used in the test.
The test item can be classed as a substance of unknown or variable composition, therefore, under EC regulation 286/2011 the 60% pass level can be determined after 28 days and the 10-day window pass level can be waived. The test item attained 63% biodegradtaion after 28 days and can be considered readily biodegradable under the conditions of the test.
Reference
Day |
% Biodegradation |
||
Test item |
Toxicity control |
Reference item |
|
0 |
0 |
0 |
0 |
5 |
35 |
77 |
72 |
10 |
49 |
86 |
80 |
15 |
55 |
88 |
84 |
20 |
59 |
88 |
85 |
25 |
62 |
88 |
86 |
28 |
63 |
89 |
86 |
Description of key information
The test item can be classed as a substance of unknown or variable composition, therefore, under EC regulation 286/2011 the 60% pass level can be determined after 28 days and the 10-day window pass level can be waived. The test item showed 63% biodegradation at the end of the test (Day 28) and may be considered readily biodegradable under the conditions of the test. The reference item attained 83% biodegradation after 14 days confirming that sewage sludge inoculum was responding normally. The toxicity control attained 89% biodegradation after 28 days indicating the test item was not toxic to the sewage treatment micro-organisms used in the test.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
- Type of water:
- freshwater
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.