Isooctadecanoic acid, monoester with propane-1,2-diol

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

12 Jan 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

GLP compliance:

no

Type of method:

column elution method

Water solubility:

< 0.02 mg/L

Temp.:

20 °C

Remarks on result:

other: The concentration of the sample was be below the limit of quantification of the analytical method.

Preliminary test results

The solubility was low, in this instance more time was required to attempt dissolve the substance, the substance was left for 96 hours at 20 °C while being shaken in an incubator. Since the test substance had not dissolved after 96 hours it was considered insoluble.

	0.1 g in 0.1 mL	0.1 g in 0.5 mL	0.1 g in 1 mL	0.1 g in 2 mL	0.1 g in 10 mL	0.1 g in 100 mL	0.1 g in 1000 mL
Approximate solubility in g/L	<1000	1000 to 200	200 to 100	100 to 50	50 to 10	10 to 1	<1
Dissolved (Y) not dissolved (N)	N	N	N	N	N	N	N

 

The preliminary results showed that the solubility of the sample was less than 0.1 g/L.

 

 

Main test results

Below is a summary of the details of the final 5 samples taken at each flow rate. These were 5 consecutive samples below the limit of quantification so no further fractions were collected.

Date/Time	Temp (°C)	Column A			Column B
		Flow Rate (mL/min)	Time (min)	Calculated Conc (mg/L)	Flow rate (mL/min)	Time (min)	Calculated Conc (mg/L)
12/01/18 15:40	20 ± 0.5	1	280	< 0.02	2	280	< 0.02
12/01/18 16:00	20 ± 0.5	1	No Sample at time point		2	300	< 0.02
12/01/18 16:20	20 ± 0.5	1	320	< 0.02	2	320	< 0.02
12/01/18 16:40	20 ± 0.5	1	No Sample at time point		2	340	< 0.02
12/01/18 17:00	20 ± 0.5	1	360	< 0.02	2	360	< 0.02
12/01/18 17:20	20 ± 0.5	1	No Sample at time point
12/01/18 17:40	20 ± 0.5	1	400	< 0.02
12/01/18 18:00	20 ± 0.5	1	No Sample at time point
12/01/18 18:20	20 ± 0.5	1	440	< 0.02

 

The concentration of the sample was shown to be below the limit of quantification at both flow rates.

Description of key information

Water solubility: < 0.02 mg/L at 20 °C (OECD guideline 105, column elution method)

Additional information

The water solubility of the test item is below the detection limit of the analytical method (0.02 mg/L) and hence appears insoluble in water.