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EC number: 904-797-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP guideline study with some reporting deficits, no appropriate positive control
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Contact allergy to chlorocresol, formaldehyde and other biocides.
- Author:
- Andersen, K.E.
- Year:
- 1 986
- Bibliographic source:
- Acta Dermato-Verereologica, Supplementum 125, pp. 2-21.
- Reference Type:
- publication
- Title:
- The Sensitising Potential of Metalworking Fluid Biocides (Phenolic and Thiazole Compounds) in the Guinea-Pig Maximization Test in relation to Patch Test Reactivity in Eczema Patients.
- Author:
- Andersen, K.E. and Hamann, K.
- Year:
- 1 984
- Bibliographic source:
- Department of Dematology, Gentofte Hospital, Hellerup, Denmark. Fd. Chem. Toxic. 22(8), pp 655-660, 1984
Materials and methods
- Principles of method if other than guideline:
- No guideline; the method used essentially follows the procedure for the GPMT (Magnusson-Kligman, 1970) laid down in Directive 96/54/EC Method B.6.
- GLP compliance:
- no
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- Intracutaneous in-vivo test with Guinea pigs was performed before the LLNA was set as preferred test method.
Test material
- Reference substance name:
- Biphenyl-2-ol
- EC Number:
- 201-993-5
- EC Name:
- Biphenyl-2-ol
- Cas Number:
- 90-43-7
- Molecular formula:
- C12H10O
- IUPAC Name:
- biphenyl-2-ol
- Details on test material:
- o-phenylphenol
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Vehicle:
- other: propylene glycol (PG) for the intradermal induction; for induction and challenge patch tests yellow petroleum was used
- Route:
- intradermal
- Vehicle:
- propylene glycol
- Concentration / amount:
- 0.5 % intracutaneous
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: yellow petroleum
- Concentration / amount:
- 25 %
Challengeopen allclose all
- Vehicle:
- other: propylene glycol (PG) for the intradermal induction; for induction and challenge patch tests yellow petroleum was used
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: yellow petroleum
- Concentration / amount:
- 5 %
- Details on study design:
- 1st application: Induction 0.5 % intracutaneous
(on day 0)
2nd application: Induction 25 % occlusive epicutaneous (on day 7)
3rd application: Challenge 5 % occlusive epicutaneous (on day 21)
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 5 %
- Total no. in group:
- 20
- Remarks on result:
- no indication of skin sensitisation
- Key result
- Reading:
- 2nd reading
- Hours after challenge:
- 72
- Group:
- test chemical
- Dose level:
- 5 %
- Total no. in group:
- 20
- Remarks on result:
- no indication of skin sensitisation
- Group:
- negative control
- Remarks on result:
- other: no details specified
- Remarks:
- .
- Group:
- positive control
- Remarks on result:
- other: no details specified
- Remarks:
- .
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Conclusions:
- OPP has been shown to be not skin sensitising according to the results of the present investigation.
- Executive summary:
The sensitising potential of seven industrial antimicrobial agents (including biphenyl-2 -ol (OPP) and its sodium salt, SOPP) was evaluated using the guinea pig maximisation test. Out-bred female albino guinea pigs (350-450 g) were used for the test. Propylene glycol was used as a vehicle for OPP while SOPP was dissolved in water. Moderately irritant concentrations were assessed in an irritancy test on a maximum of 4 guinea pigs and used for the topical inductions. For the challenge a non-irritant concentration and dilutions thereof were used. The tests were done in series of up to five groups of 20 guinea pigs. Four compounds could be tested simultaneously, 20 animals were used as controls and treated with vehicle only. In the series where four biocides were tested simultaneously, the control animals were challenged with the four biocides in the highest non-irritant challenge concentration. OPP and SOPP were tested at two concentrations in a total of 80 animals. The concentrations in vehicle were 0.5% or 5% for the intradermal induction (day 0) and 25% for the topical induction (day 7), for both compounds. The challenge was done on day 21 with a 5% concentration. In one case, the challenge was repeated after 1-2 weeks. The right and left flanks were used alternately. Blind reading of challenge reactions was done at 48 and 72 h. The Magnusson-Kligman grading scale was used to evaluate the challenge reactions. A grade 1 reaction was not regarded as sensitisation. The overall classification is based on the day 21 reading. OPP has been shown to be not skin sensitising according to the results of the present investigation.
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