4-methylbenzyl alcohol

Endpoint summary

Description of key information

Oral (comparable to OECD 401), rat: LD50 = 3900 mg/kg bw

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1978

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods with acceptable restrictions

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

TEST ANIMALS
no details available

ENVIRONMENTAL CONDITIONS
no details available

Route of administration:

oral: gavage

Vehicle:

not specified

Details on oral exposure:

no details available

Doses:

1220, 2470, 5000, 10140 mg/kg bw

No. of animals per sex per dose:

10 animals / dose

Control animals:

other: not required

Details on study design:

no details available

Preliminary study:

no details available

Key result

Sex:

not specified

Dose descriptor:

LD50

Effect level:

3 900 mg/kg bw

Based on:

test mat.

95% CL:

> 2 700 - < 5 500

Mortality:

1220 mg/kg bw: 0/10
2470 mg/kg bw: 1/10
5000 mg/kg bw: 8/10
10140 mg/kg bw: 10/10

Clinical signs:

other: 1220 mg/kg bw: Chromorhinorrhea, piloerection, lethargy 2470 mg/kg bw: Diarrhea, chromorhinorrhea, piloerection, lethargy, prostration, ataxia, ptosis, chromodacryorrhea, tachypnea, tremors, right eye crust shut 5000 mg/kg bw: Piloerection, lethargy, ptos

Gross pathology:

see table below

Necropsy observations:

Doses mg/kg	1220	2470	5000	10140
Normal	8	9	1
Cannibalized		1
Exudate, nose/mouth, yellow			2	3
Intestines, areas red			7	8
Intestines, areas yellow			5	10
Intestines, bloated				1
Stomach, areas red			9
Liver dark			7	7
Liver mottled			1
Lungs dark			5	5
Lungs areas dark			2	4
Kidney dark				6
Kidney mottled	1		1
Kidney pale			1
Spleen large	1

Conclusions:

In an acute oral toxicity study the LD50 was determined to be 3900 mg/kg bw.

Executive summary:

In a study performed 1978, the acute oral toxicity of the test item was determined. The study was conducted with 10 rats per group. The test item was administered in doses of 1220, 2470, 5000 and 10140 mg/kg bw. The animals were observed for mortality and/or systemic effects. Mortality was observed in doses from 2470 mg/kg bw onwards. The LD50 was determined to be 3900 mg/kg bw.

Endpoint conclusion

Endpoint conclusion:

adverse effect observed

Dose descriptor:

LD50

Value:

3 900 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion

Endpoint conclusion:

no study available

Acute toxicity: via dermal route

Endpoint conclusion

Endpoint conclusion:

no study available

Additional information

In a study performed 1978, the acute oral toxicity of the test item was determined. The study was conducted with 10 rats per group. The test item was administered in doses of 1220, 2470, 5000 and 10140 mg/kg bw. The animals were observed for mortality and/or systemic effects. Mortality was observed in doses from 2470 mg/kg bw onwards. The LD50 was determined to be 3900 mg/kg bw.

Justification for classification or non-classification

The available experimental test data are reliable and suitable for classification purposes under Regulation (EC) No 1272/2008. Based on available data on acute toxicity, the test item is not classified according to Regulation (EC) No 1272/2008 (CLP), as amended for the tenth time in Regulation (EU) No 2017/776.