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Diss Factsheets
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EC number: 215-355-9 | CAS number: 1323-42-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to microorganisms, other
- Remarks:
- Study was a toxicity control conducted as part of a CO2 evolution test in accordance with OECD Guideline 301B.
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 21 March 2017 to 19 April 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: According to OECD 310B and EU C.4-C
- Version / remarks:
- Toxicity test performed as part of a ready biodegradability CO2 evolution test performed according to OECD 301B and EU C.4-C.
- Deviations:
- yes
- Remarks:
- The temperatures in a non-test vessel were recorded at 24.8, 24.9 and 24.8 °C on days 19, 25, and 26 of the test respectively, outside the specified range of 22 ± 2 °C; deviation did not affect study integrity since all validation criteria were met.
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- The test substance is listed as Naturechem® GMHS (Glycerol Monohydroxystearate). The test substance is an off white solid. The test substance was obtained from the Sponsor, Vertellus Holdings LLC and stored at room temperature in the dark.
- Analytical monitoring:
- yes
- Vehicle:
- no
- Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Details on inoculum:
- A mixed population of activated sewage sludge micro-organisms was obtained on 20 March 2017 from the aeration stage of the Severn Trent Water Plc sewage treatment plant at Loughborough, Leicestershire, UK, which treats domestic sewage.
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 28 d
- Nominal and measured concentrations:
- A toxicity control, containing the test item and sodium benzoate was prepared to assess any toxic effect of the test item on the sewage sludge micro-organisms used in the test. The amount of the test item was dispersed directly in mineral medium with the aid of high shear mixing prior to dispersal in inoculated mineral medium with the aid of high shear mixing. An aliquot (51.4 mL) of the sodium benzoate stock solution was aldded to the test vessel and the volume adjusted to 3 liters to give a final nominal concentration of 14.9 mg test item//L plus 17.1 mg sodium benzoate/L, equivalent to a total of 20 mg carbon/L.
- Key result
- Duration:
- 14 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 14.9 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: : inhibition of CO2 evolution
- Remarks on result:
- other:
- Remarks:
- Toxicity test performed as part of a ready biodegradability CO2 evolution test performed according to OECD 301B and EU C.4-C.
- Details on results:
- At a test substance concentration of 14.9 mg/L and a reference substance concentration of 17.1 mg sodium benzoate/L, the toxicity control attained 40% degradation after 14 days and 55% degradation after 28 days, thereby confirming that the test substance did not exhibit an inhibitory effect on the sewage treatment micro-organisms used in the test (i.e., test substance and reference substance attained ≥ 25% degradation by Day 14 for the test substance to be considered as non-inhibitory).
- Validity criteria fulfilled:
- yes
- Remarks:
- IC content 0% & 2% (protocol ≤ 5%); CO2 emitted by controls 32.70 mg/L (protocol <70 mg/L; difference replicates less than 20% (protocol ≤20 %); degradation positive control 87% at 14 d (protocol ≤14 d); degradation toxicity d 14, 40% (protocol > 25%).
- Conclusions:
- The test substance is considered as not toxic towards the inoculum at a concentration of 14.9 mg/L. Degradation in the toxicity flask was 40% after 14 days. The guideline indicates that the test item can be considered as toxic towards the inoculum if degradation in the toxicity flask is below 25% after 14 days.
Reference
Description of key information
The key study was a toxicity control conducted as part of a CO2 evolution test in accordance with OECD Guideline 301B. The test substance was shown to be non-inhibitory toward the inoculum at a concentration of 14.9 mg/L. Degradation in the toxicity flask was 40% after 14 days.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 14.9 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.