Naphthenic acids, lithium salts

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

06 November - 09 November 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Version / remarks:

30 May 2008

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

23 March 2006

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

effusion method: vapour pressure balance

Specific details on test material used for the study:

- Source and lot/batch No.of test material: A065/99
- Expiration date of the lot/batch: 1st July 2019
- Purity: UVCB

Key result

Test no.:

#1

Temp.:

25 °C

Vapour pressure:

ca. 0 - < 0.003 Pa

Run 7

Table 1 – Vapor Pressure Data

Temperature (ºC)	Temperature (K)	Reciprocal Temperature (K-1)	Mass Difference (μg)	Mass Difference (kg)	Vapor Pressure (Pa)	Log10(kg)
120	393.15	0.002543558	36.64	3.664E-08	0.050865707	-1.293574914
121	394.15	0.002537105	38.04	3.804E-08	0.052809266	-1.277289870
122	395.15	0.002530685	31.35	3.135E-08	0.043521832	-1.361292834
123	396.15	0.002524296	34.15	3.415E-08	0.047408949	-1.324139671
124	397.15	0.002517940	32.35	3.235E-08	0.044910088	-1.347656094
125	398.15	0.002511616	34.15	3.415E-08	0.047408949	-1.324139671
126	399.15	0.002505324	39.54	3.954E-08	0.054891650	-1.260493714
127	400.15	0.002499063	34.45	3.445E-08	0.047825426	-1.320341152
128	401.15	0.002492833	39.84	3.984E-08	0.055308127	-1.257211049
129	402.15	0.002486634	35.64	3.564E-08	0.049477451	-1.305592683
130	403.15	0.002480466	40.64	4.064E-08	0.056418732	-1.248576679

Run 8

Table 2 – Vapor Pressure Data

Temperature (ºC)	Temperature (K)	Reciprocal Temperature (K-1)	Mass Difference (μg)	Mass Difference (kg)	Vapor Pressure (Pa)	Log10 Vp
120	393.15	0.002543558	29.55	2.955E-08	0.041022971	-1.386972894
121	394.15	0.002537105	28.46	2.846E-08	0.039509771	-1.403295483
122	395.15	0.002530685	33.35	3.335E-08	0.046298344	-1.334434540
123	396.15	0.002524296	29.45	2.945E-08	0.040884145	-1.388445080
124	397.15	0.002517940	28.66	2.866E-08	0.039787423	-1.400254193
125	398.15	0.002511616	30.35	3.035E-08	0.042133576	-1.375371683
126	399.15	0.002505324	30.65	3.065E-08	0.042550052	-1.371099900
127	400.15	0.002499063	31.85	3.185E-08	0.044215960	-1.354420942
128	401.15	0.002492833	32.95	3.295E-08	0.045743042	-1.339674960
129	402.15	0.002486634	35.14	3.514E-08	0.048783323	-1.311728622
130	403.15	0.002480466	37.64	3.764E-08	0.052253963	-1.281880764

 

Run 9

Table 3 – Vapor Pressure Data

Temperature (ºC)	Temperature (K)	Reciprocal Temperature (K-1)	Mass Difference (μg)	Mass Difference (kg)	Vapor Pressure (Pa)	Log10 Vp
120	393.15	0.002543558	28.66	2.866E-08	0.039787423	-1.400254193
121	394.15	0.002537105	27.66	2.766E-08	0.038399166	-1.415678203
122	395.15	0.002530685	26.56	2.656E-08	0.036872085	-1.433302308
123	396.15	0.002524296	27.16	2.716E-08	0.037705038	-1.423600613
124	397.15	0.002517940	26.66	2.666E-08	0.037010910	-1.431670234
125	398.15	0.002511616	27.86	2.786E-08	0.038676818	-1.412549267
126	399.15	0.002505324	28.46	2.846E-08	0.039509771	-1.403295483
127	400.15	0.002499063	28.66	2.866E-08	0.039787423	-1.400254193
128	401.15	0.002492833	30.35	3.035E-08	0.042133576	-1.375371683
129	402.15	0.002486634	29.25	2.925E-08	0.040606494	-1.391404508
130	403.15	0.002480466	33.05	3.305E-08	0.045881867	-1.338358915

 

Run 10

Table 4 – Vapor Pressure Data

Temperature (ºC)	Temperature (K)	Reciprocal Temperature (K-1)	Mass Difference (μg)	Mass Difference (kg)	Vapor Pressure (Pa)	Log10 Vp
120	393.15	0.002543558	28.95	2.895E-08	0.040190017	-1.395881811
121	394.15	0.002537105	25.26	2.526E-08	0.035067352	-1.455097033
122	395.15	0.002530685	24.16	2.416E-08	0.033540270	-1.474433449
123	396.15	0.002524296	25.06	2.506E-08	0.034789700	-1.458549312
124	397.15	0.002517940	26.56	2.656E-08	0.036872085	-1.433302308
125	398.15	0.002511616	25.76	2.576E-08	0.035761480	-1.446584520
126	399.15	0.002505324	29.45	2.945E-08	0.040884145	-1.388445080
127	400.15	0.002499063	26.26	2.626E-08	0.036455608	-1.438235657
128	401.15	0.002492833	27.06	2.706E-08	0.037566213	-1.425202586
129	402.15	0.002486634	27.66	2.766E-08	0.038399166	-1.415678203
130	403.15	0.002480466	32.75	3.275E-08	0.045465391	-1.342319074

 

 

 

 

 

 

Conclusions:

In conclusion, the vapour pressure of the test item has been determined to be less than 0.0025 Pa at 25°C.

Executive summary:

Envigo (2018) is a GLP-compliant study following OECD guideline 104. The vapour pressure balance effusion method was applied for the determination of the vapour pressure of the test item. The study is assigned a Klimisch score of 1 (reliable without restrictions). No statistical analyses were performed because the balance readings were too low and variable for a line of best fit to have any meaning. Instead, it was considered more appropriate to impose a regression slope on a chosen data point to provide an estimate of the maximum value for the vapor pressure at 25ºC. The vapour pressure of the test item at 25°C was determined to be less than 0.0025 Pa.

Description of key information

The vapour pressure of the test item has been determined to be less than 0.0025 Pa at 25°C.

Key value for chemical safety assessment

Vapour pressure:

0.003 Pa

at the temperature of:

25 °C

Additional information

Envigo (2017) is a GLP-compliant study following OECD guideline 104. The vapour pressure balance effusion method was applied for the determination of the vapour pressure of the test item. The study is assigned a Klimisch score of 1 (reliable without restrictions). The vapour pressure of the test item at 25°C was 0.0025 Pa.

As lithium naphthenate is a UVCB consisting of a large number of different constituents, vapour pressure values have been predicted for representative structures within the UVCB. The vapour pressure QSAR study is assigned a realiability score of 2 (reliable with restrictions) as it is an accepted calculation method. The vapour pressure of the represenative structures for lithium naphthenate were estimated with the QSAR model (MPVPBP) using the Modified Grain Method. The QSAR estimated vapour pressures of representative constituents of lithium naphthenate are in the range of 1.69 E-11 to 31.5 Pa.