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Diss Factsheets
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EC number: 204-701-4 | CAS number: 124-43-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
- Reference Type:
- review article or handbook
- Title:
- Wasserstoffperoxid
- Author:
- Deutsche Forschungsgemeinschaft (DFG). Senatskommission zur Prüfung gesundheistschädlicher Arbeitsstoffe
- Year:
- 2 006
- Bibliographic source:
- Wiley Online Library. The MAK Collection for Occupational Health and Safety.
- Report date:
- 2006
Materials and methods
Test guideline
- Guideline:
- other: patch test in humans; technical details not reported
- Deviations:
- not applicable
- Principles of method if other than guideline:
- - Principle of test: pactch in humans
- Short description of test conditions: not available - GLP compliance:
- not specified
- Type of study:
- patch test
- Justification for non-LLNA method:
- existing data
Test material
- Reference substance name:
- Hydrogen peroxide
- EC Number:
- 231-765-0
- EC Name:
- Hydrogen peroxide
- Cas Number:
- 7722-84-1
- Molecular formula:
- H2O2
- IUPAC Name:
- hydrogen peroxide
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- CAS number: 7722-84-1
Purity: not stated
In vivo test system
Test animals
- Species:
- other: human
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals and environmental conditions:
- -cohort of hairdresses with allergic dermatitis (Leino et al., 1998)
-two cohorts of dermazitis patiemts (Kanerva et al., 1985)
Study design: in vivo (non-LLNA)
Induction
- Route:
- intradermal and epicutaneous
- Vehicle:
- not specified
- Concentration / amount:
- not specified
- Day(s)/duration:
- not specified
- Adequacy of induction:
- not specified
Challenge
- No.:
- #1
- Route:
- other: not specified; patch test in humans
- Vehicle:
- not specified
- Concentration / amount:
- not specified
- Day(s)/duration:
- not specified
- Adequacy of challenge:
- not specified
- No. of animals per dose:
- - 35 hairdresses with allrgic dermatitis (Leino eta al. 1998)
- 54 hairdressers out of acohort of 355 patients (Leino et al. 1998)
- two studies with 130 and 59 pateints, respectively (Kanerva et al. 1998) - Details on study design:
- No other details are reported apart from human patch testing in dermatitis patients without or with conatct to hydrogen peroxide conatining materials (hairdressers)
- Positive control substance(s):
- not specified
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Key result
- Reading:
- other: study Leino et al. (1998)
- Group:
- test chemical
- Dose level:
- not reported
- No. with + reactions:
- 0
- Total no. in group:
- 35
- Clinical observations:
- not reported
- Remarks on result:
- other: hairdressers with allergic dermatitis
- Key result
- Reading:
- other: study Leino et al. (1998b) hairdressers with allergic dermatitis
- Group:
- test chemical
- No. with + reactions:
- 0
- Total no. in group:
- 54
- Clinical observations:
- not reported
- Remarks on result:
- other: 54 hairdressers in a cohort of 355 patienst
- Key result
- Reading:
- other: study Kaverna et al. (1998)
- Group:
- test chemical
- No. with + reactions:
- 0
- Total no. in group:
- 130
- Clinical observations:
- not reported
- Remarks on result:
- other: dermatitis patients were examined
- Key result
- Reading:
- other: study Kaverna et al. (1998)
- Group:
- test chemical
- Dose level:
- not reported
- No. with + reactions:
- 0
- Total no. in group:
- 59
- Clinical observations:
- not reported
- Remarks on result:
- other: dermatitis patients were examined
Any other information on results incl. tables
References cited in the assesements:
Kanerva L, Jolanki V, Riihimäki V, Kalimo K (1998) Patch test reactions and occupational dermatoses
caused by hydrogen peroxide. Contact Dermatitis 39: 146
Leino T, Estlander T, Kanerva L (1998 a) Occupational allergic dermatoses in hairdressers. Contact Dermatitis 38: 166–167
Leino T, Tammilehto L, Hytönen M, Sala E, Paakulainen H, Kanerva L (1998 b) Occupational skin and respiratory diseases among hairdressers. Scand J Work Environ Health 24: 398–406
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In several independent studies in patients with allergic dermatitis and/or occupational contact with hydrogen peroxide containing materials no skin sensitising potential of hydrogen peroxide was determined.
- Executive summary:
According to the ECB (2005) and DFG (2006) assessment reports, the skin sensitising potential of hydrogen peroxide was examined in several independent studies in patients with allergic dermatitis and/or occupational contact with hydrogen peroxide containing materials.
All tests conducted during 1974-1993 in 35 hairdressers were negative (Leino et al., 1998a), as well as the tests in another 54 hairdressers (Leino et al., 1998b). Negative results were also obtained in another two studies with either 130 or 59 patients, conducted during 1991 and 1997 (Kanerva et al., 1985).
Further, the Finnish Register of Occupational Diseases, which was searched from 1975 through 1997 for cases of allergic dermatosis caused by hydrogen peroxide, did not contain any such case among the total of 29,800 cases of allergic dermatosis.
The finds of the human patch tests are considered to be valid and suitable to demonstrate that hydrogen peroxide lacks a skin sensitising potential.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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