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Diss Factsheets
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EC number: 947-945-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Link to relevant study records
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction
- Principles of method if other than guideline:
- Data is predicted by QSAR toolbox version 3.2
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
- Species / strain / cell type:
- S. typhimurium TA 102
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- without
- Species / strain:
- S. typhimurium TA 102
- Metabolic activation:
- without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
- Conclusions:
- Interpretation of results (migrated information):negativeBased on the QSAR prediction done for Reaction mass of Cardanol diene and Cardanol monoene and Cardanol triene for genetic toxicity on S. typhimurium TA 102 it was estimated to give negative result in gene mutation. Based on these results it can be concluded that Cardanol is not genetoxic substance.
- Executive summary:
Based on the QSAR prediction done for Reaction mass of Cardanol diene and Cardanol monoene and Cardanol triene for genetic toxicity on S. typhimurium TA 102 it was estimated to give negative result in gene mutation. Based on these results it can be concluded that Cardanol is not genetoxic substance.
Reference
The prediction was based on dataset comprised from the following descriptors: "Gene mutation"
Estimation method: Takes highest mode value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
((((((("a" or "b" or "c" or "d" or "e" or "f" ) and ("g" and ( not "h") ) ) and ("i" and ( not "j") ) ) and "k" ) and ("l" and ( not "m") ) ) and "n" ) and ("o" and "p" ) )
Domain logical expression index: "a"
Referential boundary: The target chemical should be classified as Phenols (Chronic toxicity) by US-EPA New Chemical Categories
Domain logical expression index: "b"
Referential boundary: The target chemical should be classified as Alkene AND Allyl AND Aryl AND Benzyl AND Phenol by Organic functional groups
Domain logical expression index: "c"
Referential boundary: The target chemical should be classified as Allyl AND Benzyl AND Overlapping groups AND Phenol by Organic functional groups (nested)
Domain logical expression index: "d"
Referential boundary: The target chemical should be classified as Alcohol, olefinic attach [-OH] AND Aliphatic Carbon [CH] AND Aliphatic Carbon [-CH2-] AND Aliphatic Carbon [-CH3] AND Aromatic Carbon [C] AND Hydroxy, aromatic attach [-OH] AND Olefinic carbon [=CH- or =C<] AND Olefinic carbon [=CH2] AND Oxygen, one aromatic attach [-O-] by Organic functional groups (US EPA)
Domain logical expression index: "e"
Referential boundary: The target chemical should be classified as Aromatic compound AND Hydroxy compound AND Phenol by Organic functional groups, Norbert Haider (checkmol)
Domain logical expression index: "f"
Similarity boundary:Target: c1(O)cc(CCCCCCCC=CCC=CCCC)ccc1_c1(O)cc(CCCCCCCCCCCCCCC)ccc1_c1(O)cc(CCCCCCCC=CCC=CCC=C)ccc1_c1(O)cc(CCCCCCCC=CCCCCCC)ccc1
Threshold=50%,
Dice(Atom centered fragments)
Domain logical expression index: "g"
Referential boundary: The target chemical should be classified as No alert found by DNA binding by OASIS v.1.1
Domain logical expression index: "h"
Referential boundary: The target chemical should be classified as Michael addition OR Michael addition >> alpha, beta-unsaturated carabonyl compounds OR Michael addition >> alpha, beta-unsaturated carabonyl compounds >> Four- and Five-Membered Lactones OR Michael addition >> Quinone type compounds OR Michael addition >> Quinone type compounds >> Quinones OR Radical OR Radical >> Generation of reactive oxygen species OR Radical >> Generation of reactive oxygen species >> Coumarins OR Radical >> Radical mechanism by ROS formation OR Radical >> Radical mechanism by ROS formation >> Nitro Compounds OR Radical >> Radical mechanism by ROS formation >> Quinones OR Radical >> ROS formation after GSH depletion OR Radical >> ROS formation after GSH depletion >> Aromatic and Heterocyclic Primary Amines OR SN1 OR SN1 >> Nitrenium ion formation OR SN1 >> Nitrenium ion formation >> Aromatic and Heterocyclic Primary Amines OR SN1 >> Nitrenium ion formation >> N-hydroxylamines OR SN1 >> Nitrenium ion formation >> Nitro Compounds OR SN2 OR SN2 >> Nucleophilic substitution at sp3 Carbon atom OR SN2 >> Nucleophilic substitution at sp3 Carbon atom >> Haloalkanes Containing Heteroatom OR SN2 >> P450-mediated epoxidation OR SN2 >> P450-mediated epoxidation >> Coumarins OR SN2 >> Ring opening SN2 reaction OR SN2 >> Ring opening SN2 reaction >> Four- and Five-Membered Lactones by DNA binding by OASIS v.1.1
Domain logical expression index: "i"
Referential boundary: The target chemical should be classified as Not possible to classify according to these rules (GSH) by Protein binding potency
Domain logical expression index: "j"
Referential boundary: The target chemical should be classified as Extremely reactive (GSH) OR Extremely reactive (GSH) >> Naphthoquinones (MA) OR Highly reactive (GSH) OR Highly reactive (GSH) >> Vinylene-sub. chalcones (MA) OR Moderately reactive (GSH) OR Moderately reactive (GSH) >> Substituted 1-Alken-3-ones (MA) by Protein binding potency
Domain logical expression index: "k"
Referential boundary: The target chemical should be classified as No superfragment by Superfragments
Domain logical expression index: "l"
Referential boundary: The target chemical should be classified as Not possible to classify according to these rules by Keratinocyte gene expression
Domain logical expression index: "m"
Referential boundary: The target chemical should be classified as Low gene expression OR Low gene expression >> Vaniline derivatives OR Very high gene expression OR Very high gene expression >> Activated halo-benzenes by Keratinocyte gene expression
Domain logical expression index: "n"
Referential boundary: The target chemical should be classified as Not bioavailable by Lipinski Rule Oasis
Domain logical expression index: "o"
Parametric boundary:The target chemical should have a value of log Kow which is >= 5.91
Domain logical expression index: "p"
Parametric boundary:The target chemical should have a value of log Kow which is <= 9
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
Gene toxicity (In-vitro):
No. of studies of Cardanol reviewed for genetic toxicity from reliable sources having Klimisch rating 2 & 4.
The summary of the results are presented below
Sr.No | Endpoint | Interpretation of Results | Species/Strain | Sources |
1 | In vitro Genetic toxicity | Negative with or without metabolic activation | S. typhimurium TA 102 | Predicted data from QSAR |
2 | In vitro Genetic toxicity | Negative with or without metabolic activation | S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and TA 102 | Study report of RA Cas |
3 | Chromosome Aberration | Negative with or without metabolic activation | Chinese hamster Lung (CHL) | Predicted datafromQSAR |
4 | In vitro Genetic toxicity | Negative with or without metabolic activation | S. typhimurium TA 1535, TA 98, TA 100 | Publication of RA Cas |
5 | In vitro Genetic toxicity | Negative with or without metabolic activation | S. typhimurium TA98 and TA 100 | Publication of RA Cas |
By applying weight of evidence approach to the target & read across chemical , it can be concluded that the substance is non-genotoxic.
Gene toxicity (In-vivo):
No. of studies of Cashew nut shell liquid(CNSL) reviewed for genetic toxicity from reliable sources having Klimisch rating 2 .
The summary of the results are presented below
Sr.No | Endpoint | Interpretation of Results | Species/Strain | Sources |
1 | In vivo Genetic toxicity | Negative | A. cepa root meristems | Publication data |
3 | Chromosome Aberration | Negative | A. cepa root meristems | Publication data |
By applying weight of evidence approach to the read across chemical Cashew nut shell liquid, it can be concluded that the substance is non-genotoxic.
Justification for selection of genetic toxicity endpoint
Based on the prediction result done for Cardanol for genetic toxicity on S. typhimurium TA 102 it was estimated to give negative result in gene mutation.also it was observed that Cardanol shows negative results in Chinese hamster cultured cells. thus it can be concluded that Cardanol is not genetoxic substance.
Justification for classification or non-classification
Considering the weight of evidence appraoch from the various data available, it can be conclided that Reaction mass of Cardanol diene and Cardanol monoene and Cardanol triene (CAS No 37330 -39 -5) shall not exhibit genotoxic effects and hence is not classified as a genotixic chemical.
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