Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 906-521-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04 - 06 Jun 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 1984
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Version / remarks:
- 1992
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Niedersächsisches Umweltministerium, Hannover, Germany
Test material
- Reference substance name:
- Reaction mass of 2-hydroxyisopropyl 2-hydroxypropyl bicarbamate and 2-hydroxypropyl carbazate and propylene carbonate
- EC Number:
- 906-521-8
- Cas Number:
- 85391-60-2
- Molecular formula:
- C8H16N2O6
- IUPAC Name:
- Reaction mass of 2-hydroxyisopropyl 2-hydroxypropyl bicarbamate and 2-hydroxypropyl carbazate and propylene carbonate
- Test material form:
- liquid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: control and 100 mg/L (Limit concentration which can be achived by suitable preparation methods)
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: A stock solution was prepared one day prior to application at a concentration of 100 mg/L. The stock solution was shaken with 20 rpm for 24 h. Undissolved particles were removed by centrifugation (20 min at 3000 rpm).
- Eluate: no
- Differential loading: no
- Controls: yes, test medium control
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Source: Institut für Wasser-, Boden- und Lufthygiene des Bundesgesundheitsamt Berlin, Germany
- Feeding during test: none
- Culture: Daphnids were cultured in 2-3 L glass vessels with approx. 1.8 L culture medium (M4-medium) at 21 °C (20-25 °C); 16 h illumination (20 µmol*m-2*s-1); approx. 1200 lux. Daphnids were fed ad libitum with a mix of Scenedesmus subspicatus and Chlorella vulgaris with a cell density of >10E+06 cells/mL.
- Age at study inititation: 2-24 h; obtained by removing the mother animals twice within 22 h
ACCLIMATION
- Acclimation period: 2 h in dilution water
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 252 mg CaCO3/L (dilution water)
- Test temperature:
- 21.2 - 21.9 °C
- pH:
- 7.34 - 7.50
- Dissolved oxygen:
- 7.80 - 8.06 mg/L
- Conductivity:
- 668 µS/cm (dilution water)
- Nominal and measured concentrations:
- Nominal: control, saturated solution
measured DOC: please refer to "Any other information on results incl. tables" - Details on test conditions:
- TEST SYSTEM
- Test vessel: Glass beakers (5 cm i.d. x 8 cm), volume: 50 mL, headspace: 30 mL, fill volume: 20 mL
- Aeration: no
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: according to EEC 92/69 L383A C.2
- Culture medium different from test medium: same as test
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 h light / 8 h dark
- Light intensity: approx. 1200 lux
EFFECT PARAMETERS MEASURED
- Immobilisation after 24 and 48 h
RANGE-FINDING STUDY
- Test concentrations:
- Results used to determine the conditions for the definitive study: - Reference substance (positive control):
- yes
Results and discussion
Effect concentrations
- Duration:
- 48 h
- Dose descriptor:
- EL50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: Reported as "saturated solution"
- Details on results:
- - Mortality of control: 0%
- Results with reference substance (positive control):
- - Results with reference substance valid? yes
- Dose-response test: yes, 0.58 - 5.8 mg/L
- ECx: EC50 (24 h): 1.5 mg/L (95% CI 1.3 - 1.7 mg/L) - Reported statistics and error estimates:
- Effect concentrations were derived directly from the test results.
Any other information on results incl. tables
All validity criteria were met:
1.) pH did not vary by more than 1 unit
2.) No immobilisation was recorded in the control.
3.) EC50 value of the reference substance was between 1.0 - 2.5 mg/L.
4.) Dissolved O2 concentration was > 5.21 mg/L (60% of air saturation level)
Table 1: Results from DOC analysis
|
DOC [mg/L] |
||||
0 h (new without daphnids) |
48 h (old without daphnids) |
48 h (old media with daphnids) |
Overall mean |
Corrected vs. control |
|
Saturated solution |
43.9 |
43.37 |
51.65 |
46.31 |
41.16 |
Control |
3.22 |
3.06 |
9.17 |
5.15 |
-- |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.