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EC number: 203-600-2 | CAS number: 108-62-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August 2006 - June 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Freshwater Alga and Cyanobacteria, Growth Inhibition Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- - Name: Metaldehyde
- Physical appearance: crystalline white powder
- Storage requirements: dry and cool at a well ventilated place according to MSDS provided by the sponsor
- Stability under correct storage conditions/expiry date: 15 July 2009 - Analytical monitoring:
- yes
- Details on sampling:
- Sampling procedure:
- at the beginning of the test, duplicate samples of the stock solution will be taken
- at the beginning of the study duplicate samples of the control, and treated test solutions will be taken from the volumetric flasks
- at the end of the test immediately after determination of the biological and physicochemical parameters, the test solutions of the replicates of a given concentration will be mixed. Duplicate samples will be taken from controls and treated vessels, and from test vessels without algae at the highest test ttem concentration - Vehicle:
- no
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 72 h
- Remarks on exposure duration:
- standard test duration
- Post exposure observation period:
- none
- Hardness:
- not mentioned
- Test temperature:
- 22.8 +/- 0.24°C
- pH:
- 7.5
- Dissolved oxygen:
- no data
- Salinity:
- freshwater used
- Conductivity:
- no data
- Nominal and measured concentrations:
- The mean total recovery for all measured test solutions was 99.3% of the nominal concentration. Therefore a correction of the biological results based on measured concentrations was not perfonned.
- Test concentrations: 200, 100, 50, 25, and 12.5 mg test item/L plus a control
- Number of replicates per test concentration: 3 for test item concentrations, and 6 for control - Details on test conditions:
- - Test organisms: Desmodesmus subspicatus (SAG 86.81)
- Supplier: Sammlung für Algenkulturen (SAG), Albrecht-von-Haller lnstitut für Pflanzenwissenschaften der Universität Göttingen, D-37073 Göttingen, Germany
- Test medium: US-EPA medium AAP
- Light regime: Permanent
- Light intensity: 76.4 uE/m2 • s (required: 60-120 u/m2 • s)
- Test units: 50 mL Erlenmeyer flasks - Reference substance (positive control):
- not specified
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 200 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: EC50 for yield and growth rate
- Key result
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 25 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: yield
- Details on results:
- After an exposure period of 72 hours, the EC50 for growth rate and yield was determined to be higher than 200 mg test item/L.
- Results with reference substance (positive control):
- not tested
- Reported statistics and error estimates:
- - The statistical software package ToxRat 2.09 Professional (ToxRat Solutions GmbH, Naheweg 15, D-524 77 Alsdorf) was used for these calculations.
- Probit analysis (FINNEY, 1971) was used to calculate the ECx values. Where the calculated ECx values were extrapolated to concentrations above the highest tested concentration, the respective ECx values are reported as "> 200 mg/L".
- The Range-To-Standard-Deviation-Ratio-Test was used to test correspondence of the data with normal distribution. The data were evaluated for homogeneity of variances by Cochran's Test. One-way Analysis of Variance (ANOVA) and subsequent multi-comparison tests (Williams' Test) were used to calculate whether there were significant differences between the growth of algae in the controls and the algae exposed to the various test item concentrations. - Validity criteria fulfilled:
- yes
- Conclusions:
- After an exposure period of 72 hours, the EC50 for growth rate and yield was determined to be higher than 200 mg test item/L.
- Executive summary:
The acute toxicity of the test item to green algae (Desmodesmus subspicatus) was determined in a 72 -hour static test according to the OECD test method no. 201. A full test with five test item concentrations (200, 100, 50, 25 and 12.5 mg/L) was performed in accordance with the test guidelines. The mean total recovery for all measured test solutions was 99.3% of the nominal concentration. Therefore a correction of the biological results based on measured concentrations was not performed. After an exposure period of 72 hours, the EC50 for growth rate and yield was determined to be higher than 200 mg test item/L.
Reference
Description of key information
The acute toxicity of the test item to green algae (Desmodesmus subspicatus) was determined in a 72 -hour static test according to the OECD test method no. 201. A full test with five test item concentrations (200, 100, 50, 25 and 12.5 mg/L) was performed in accordance with the test guidelines. The mean total recovery for all measured test solutions was 99.3% of the nominal concentration. Therefore a correction of the biological results based on measured concentrations was not performed. After an exposure period of 72 hours, the EC50 for growth rate and yield was determined to be higher than 200 mg test item/L.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 200 mg/L
- EC10 or NOEC for freshwater algae:
- 25 mg/L
Additional information
Source: GLP-report
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