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Diss Factsheets
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EC number: 200-828-4 | CAS number: 74-99-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- not applicable
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: data from peer-reviewed database
Data source
Referenceopen allclose all
- Reference Type:
- other: secondary source
- Title:
- High Production Volume (HPV) Challenge Program's Robust Summaries and Test Plans for Acetylene
- Author:
- EPA, Office of Pollution Prevention and Toxics
- Year:
- 2 006
- Bibliographic source:
- EPA/Office of Pollution Prevention and Toxics; HPV Challenge Program's Robust Summaries and Test Plans for Acetylene (December 2003). Available from, as of September 10, 2006: http://www.epa.gov/chemrtk/pubs/summaries/acetylen/c15005.pdf
- Reference Type:
- secondary source
- Title:
- TOXNET
- Author:
- HSDB database
- Year:
- 2 004
- Bibliographic source:
- https://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?HSDB
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- not specified in database
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Propyne
- EC Number:
- 200-828-4
- EC Name:
- Propyne
- Cas Number:
- 74-99-7
- Molecular formula:
- C3H4
- IUPAC Name:
- prop-1-yne
- Test material form:
- gas
Constituent 1
- Specific details on test material used for the study:
- no details given
Test animals
- Species:
- rat
- Details on test animals or test system and environmental conditions:
- no details given
Administration / exposure
- Route of administration:
- inhalation
- Details on inhalation exposure:
- the animals were exposed to 28,700 ppm methylacetylene 6 hr/day, 5 days/week for 6 months
Doses / concentrations
- Dose / conc.:
- 28 700 ppm
- No. of animals per sex per dose:
- no details given
- Details on study design:
- no details given
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Description (incidence and severity):
- Rats reached an early plane of anesthesia (within 30 minutes) and generally recovered rapidly after each exposure.
- Mortality:
- mortality observed, treatment-related
- Description (incidence):
- Forty percent of the rats died over the course of the study.
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- effects observed, treatment-related
- Description (incidence and severity):
- Rats reached an early plane of anesthesia (within 30 minutes) and generally recovered rapidly after each exposure.
- Immunological findings:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- Gross pathology of the rats that died was limited to the lungs, which appeared dark red and remained distended when the thorax was opened.
In exposed rats that survived to termination, the lungs also were discolored and remained distended. - Neuropathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Description (incidence and severity):
- Microscopic pathology of the lungs showed definite pulmonary irritation.
- Histopathological findings: neoplastic:
- not specified
- Other effects:
- not specified
Effect levels
- Remarks on result:
- other: see "Any other information on results"
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Rats reached an early plane of anesthesia (within 30 minutes) and generally recovered rapidly after each exposure. Forty percent of the rats died over the course of the study. Gross pathology of the rats that died was limited to the lungs, which appeared dark red and remained distended when the thorax was opened. In exposed rats that survived to termination, the lungs also were discolored and remained distended. Microscopic pathology of the lungs showed definite pulmonary irritation. The remaining organs appeared to be within normal limits.
Applicant's summary and conclusion
- Executive summary:
There is no available information on the methods used to determine the value for this endpoint. However, this information is taken from the TOXNET website which is considered to be a reliable peer reviewed data source.
In this study, the rats were exposed to 28,700 ppm methylacetylene 6 hr/day, 5 days/week for 6 months.
Rats reached an early plane of anesthesia (within 30 minutes) and generally recovered rapidly after each exposure. Forty percent of the rats died over the course of the study. Gross pathology of the rats that died was limited to the lungs, which appeared dark red and remained distended when the thorax was opened. In exposed rats that survived to termination, the lungs also were discolored and remained distended. Microscopic pathology of the lungs showed definite pulmonary irritation. The remaining organs appeared to be within normal limits.
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