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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
to 2000-6-8
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
yes (incl. QA statement)
Test type:
standard acute method
Limit test:
no
Species:
rat
Sex:
male/female
Route of administration:
oral: gavage
Key result
Sex:
female
Dose descriptor:
LD50
Effect level:
113 mg/kg bw
95% CL:
64 - 199
Clinical signs:
other: The test substance caused effects on the autonomous and central nervous system as well as a gastro intestinal irritation together with cardiovascular changes.
Interpretation of results:
Category 3 based on GHS criteria
Conclusions:
In an acute oral toxicity study similar to OECD 401 the LD50 was determined to be 113 mg/kg bw in female rats.
Executive summary:

The test substance caused effects on the autonomous and central nervous system as well as a gastro intestinal irritation together with cardiovascular changes. These changes together may have been the cause of death. The following LD50 was calculated for females: 113 mg/kg body weight. The limits of confidence were 64 and 199 mg per kg body weight. The slope was 2.98.

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
133 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification

The test substance has an LD50 for females of 113 mg/kg body weight. According to regulation (EC) 1272/2008 (CLP), the test item is classified for acute oral toxicity (Acute 3, H301).