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EC number: 239-044-2 | CAS number: 14970-87-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Version / remarks:
- 1992
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- Study performed before the implementation of the REACH regulation
Test material
- Reference substance name:
- 2,2'-[1,2-ethanediylbis(oxy)]bis(ethanethiol)
- EC Number:
- 239-044-2
- EC Name:
- 2,2'-[1,2-ethanediylbis(oxy)]bis(ethanethiol)
- Cas Number:
- 14970-87-7
- Molecular formula:
- C6H14O2S2
- IUPAC Name:
- 2,2'-[1,2-ethanediylbis(oxy)]bis(ethanethiol)
- Test material form:
- liquid
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Dunkin-Hartley
- Sex:
- male/female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: Charles River France, 76410 Saint-Aubin-lès-Elbeuf, France
- Females nulliparous and non-pregnant: yes
- Microbiological status of animals, when known:
- Age at study initiation: approximately three months old
- Weight at study initiation: 354 ± 11 g for the males and 335 ± 15 g for the females
- Housing: individually in polycarbonate cages
- Diet: "106 pelleted diet" (U.A.R., 91360 Villemoisson-sur-Orge, France), ad libitum
- Water: water filtered by a F.G. Millipore membrane (0.22 micron), ad libitum
- Acclimation period: at least 5 days
- Indication of any skin lesions: none
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21±2
- Humidity (%): 30 to 70
- Air changes (per hr): 12 cycles/hour of filtered, non-recycled air
- Photoperiod (hrs dark / hrs light): 12/12
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal
- Vehicle:
- paraffin oil
- Concentration / amount:
- 5 %
- Day(s)/duration:
- Day 1
- Adequacy of induction:
- highest concentration used causing mild-to-moderate skin irritation and well-tolerated systemically
- Route:
- epicutaneous, occlusive
- Vehicle:
- unchanged (no vehicle)
- Concentration / amount:
- 100 %
- Day(s)/duration:
- Day 8
- Adequacy of induction:
- non-irritant substance, but skin pre-treated with 10% SDS
Challenge
- Route:
- epicutaneous, occlusive
- Vehicle:
- paraffin oil
- Concentration / amount:
- 10 %
- Day(s)/duration:
- Day 22
- Adequacy of challenge:
- highest non-irritant concentration
- No. of animals per dose:
- 10
- Details on study design:
- On day 1, intradermal injections of Freund's complete adjuvant mixed with the test substance (treated group) or the vehicle (control group) were performed in the interscapular region.
On day 8, this same test site received a cutaneous application of the test substance (treated group) or the vehicle (control group) and was then covered by an occlusive dressing for 48 hours.
On day 22, after a rest period of 12 days, ail animais of the treated and control groups were challenged by a cutaneous application of the test substance to the right flank. The left flank served as control and received the vehicle only. Test substance and vehicle were maintained under an occlusive dressing for 24 hours.
Skin reactions were evaluated approximately 24 and 48 hours after removal of the dressing.
Test substance concentrations were as follows:
Induction (treated group)
intradermal injections: 1,8-DIMERCAPT0-3,6-DIOXAOCTANE at the concentration of 5% (w/w) in paraffin oil
. topical application: l,8-DIMERCAPT0-3,6-DIOXAOCTANE undiluted.
Challenge (all groups)
topical application: 1,8-DIMERCAPT0-3,6-DIOXAOCT ANE at the concentration of 10% (w/w) in paraffin oil
At the end of the study, animais were killed without examination of internai organs.
No skin samples were taken from the challenge application sites. - Challenge controls:
- left flank: vehicle
right flank: test substance at the concentration of 10 % (w/w) - Positive control substance(s):
- yes
- Remarks:
- DNCB and MERCAPTOBENZOTHIAZOLE
Results and discussion
- Positive control results:
- The species and strain which were used showed a satisfactory sensitization response in 90% animais treated with DNCB and in 30% animais treated with MERCAPTOBENZOTHIAZOLE.
In vivo (non-LLNA)
Resultsopen allclose all
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- 10%
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Key result
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- 10%
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 10%
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Remarks on result:
- no indication of skin sensitisation
- Key result
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 10%
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Remarks on result:
- no indication of skin sensitisation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- 1,8-DIMERCAPT0-3,6-DIOXAOCTANE does not induce delayed contact hypersensitivity in guinea-pigs.
- Executive summary:
The potential of 1,8-DIMERCAPT0-3,6-DIOXAOCTANE to induce delayed contact hypersensitivity was evaluated in guinea-pigs according to the maximization method of Magnusson and Kligman and to O.E.C.D. (No. 406, l 7th July 1992) and E.C. (92/69/E.E.C., B6, 31st July 1992) guidelines. The study was conducted in compliance with the Principles of Good Laboratory Practice Regulations. Thirty guinea-pigs were allocated to two groups: a control group 1 (five males and five females) and a treated group 2 (ten males and ten females). On day 1, intradermal injections of Freund's complete adjuvant mixed with the test substance (treated group) or the vehicle (control group) were performed in the interscapular region. On day 8, this same test site received a cutaneous application of the test substance (treated group) or the vehicle (control group) and was then covered by an occlusive dressing for 48 hours. On day 22, after a rest period of 12 days, all animals of the treated and control groups were challenged by a cutaneous application of the test substance to the right flank. The left flank served as control and received the vehicle only. Test substance and vehicle were maintained under an occlusive dressing for 24 hours. Skin reactions were evaluated approximately 24 and 48 hours after removal of the dressing.
Test substance concentrations were as follows:
Induction (treated group):
. intradermal injections: 1,8-DIMERCAPT0-3,6-DIOXAOCTANE at the concentration of 5% (w/w) in paraffin oil
. topical application: l,8-DIMERCAPT0-3,6-DIOXAOCTANE undiluted.
Challenge (all groups):
. topical application: 1,8-DIMERCAPT0-3,6-DIOXAOCTANE at the concentration of 10% (w/w) in paraffin oil.
At the end of the study, animals were killed without examination of internal organs. No skin samples were taken from the challenge application sites. The sensitivity of the guinea-pigs was checked with positive sensitizers DNCB and MERCAPTOBENZOTHIAZOLE.
No clinical signs and no deaths were noted during the study. No cutaneous reactions were observed after the challenge application. The species and strain which were used showed a satisfactory sensitization response in 90% animals treated with DNCB and in 30% animals treated with MERCAPTOBENZOTHIAZOLE. 1,8-DIMERCAPT0-3,6-DIOXAOCTANE does not induce delayed contact hypersensitivity in guinea-pigs.
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