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EC number: 221-493-0 | CAS number: 3119-15-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April 1999 to Mary 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: EC guideline no. 92/69/EEC (2)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3-amino-2,4,6-triiodobenzoic acid
- EC Number:
- 221-493-0
- EC Name:
- 3-amino-2,4,6-triiodobenzoic acid
- Cas Number:
- 3119-15-1
- Molecular formula:
- C7H4I3NO2
- IUPAC Name:
- 3-amino-2,4,6-triiodobenzoic acid
- Test material form:
- solid: bulk
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Schering AG, 37055008
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- The organic carbon concentration of the test solutions were analyzed with a TOC-analyzer at the start of the exposure and 48 hours thereafter. The substance concentration was calculated on the basis of the molecular formula (C7H4IcNO2 with molecular weight of 514.828). The mean concentrations are in the following table.
Test solutions
- Vehicle:
- yes
- Remarks:
- tap water
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Source: Schering AG, Experimental Toxicology, Berlin, Germany
- Age: juveniles (for tap water control) 0-24 hours
- Feeding during test: no
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- Dilution water characteristic: 252 mg/L
- Test temperature:
- 20.7 - 22.0 degrees Celcius
- Dissolved oxygen:
- 8.2 - 8.5 mg/L
- Conductivity:
- Dilution water characteristic: 715 µS/cm
- Nominal and measured concentrations:
- For the preparation of the test solution, a solution with nominal loading of 111 mg/L was stirred for 15 minutes. The solution obtained by this procedure was used for the limit test. For the definitive test this solution was further diluted 1:1, 1:2, and 1:4 in order to obtain the final concentrations of 12.5, 25, 50, and 100 mg/L. The mean concentration of the test soltuion calculated based on TOC-analysis was within 86-105% of the nominal which was considered to be in good agreement.
- Details on test conditions:
- TEST SYSTEM
- Test vessel: not described
- Type (delete if not applicable): not reported
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- No. of vessels per vehicle control (replicates): 4
VEHICLE CONTROL PERFORMED: yes
RANGE-FINDING STUDY
- Test concentrations: 100 mg/L (limit test)
- Results used to determine the conditions for the definitive study: no mortality - Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
Any other information on results incl. tables
Nominal concentration of ZK 2218 (mg/L) | Concentration of ZK 2218 obtained by TOC-analysis (mg/L) | 24 hours | 48 hours |
0 (Limit and definitive test) control (tap water) |
---- | 0 | 0 |
100 (limit test) | 104 | 0 | 0 |
12.5 | 11.00 | 1 | 3 |
25 | 21.00 | 0 | 1 |
50 | 47.00 | 0 | 0 |
100 | 105.00 | 0 | 0 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The results of the first limit test were not reproducible and therefore considered as an artefact. The repeat limit test and the definitive test showed consistently the absence of a substance related efffect. Therefore, it was concluded that the EC50(48h) for the test substance to Daphnia is greater than 100 mg/L (nominal).
- Executive summary:
Daphnia magna were used to determine the toxicity of the test substance, TK 2218 using OECD 202 and EU Method EC guideline no. 92/69/EEC (2). Two limit tests and a definitive test were conducted. The results of the first limit test were not reproducible and therefore considered as an artefact. The repeat limit test and the definitive test showed consistently the absence of a substance related efffect. Therefore, it was concluded that the EC50(48h) for the test substance to Daphnia is greater than 100 mg/L (nominal).
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