Registration Dossier
Registration Dossier
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EC number: 222-940-2 | CAS number: 3674-09-7
Endpoint summary
Administrative data
Description of key information
Experimental data (acute oral and dermal toxicity tests) on this property are available.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 270 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 680 mg/kg bw
Additional information
Justification for classification or non-classification
Acute toxicity - oral
Experimental data (Acute oral toxicity test) on this property are available.
Lethal dose available is:
- LD50: 270 mg/kg (oral rat)
Considering this value, KLOB-010 is classified as Acute Tox.3; H301.
Acute toxicity - dermal
Experimental data (Acute dermal toxicity) on this property are available.
Lethal dose available is:
- LD50: 3680 mg/kg (rabbit dermal)
Considering this value, KLOB-010 is not classified for this property.
Moreover, during the toxicity studies, (i) at 100 mg/kg no toxicity was observed, (ii) at 200 and 300 mg/kg transient paresis were observed, (iii) paresis and paralysis before all animals died.
Pulmonary and gastric congestion were reported.
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