Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Cross-reference
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Vapour pressure:
- 0 Pa
- at the temperature of:
- 25 °C
The vapour pressure of the test substance was determined experimentally using the isoteniscope method, according to OECD Guideline 104 and EU Method A.4, (Chilworth, 2017) as well using QSAR models of EPI Suite and US EPA T.E.S.T. (US EPA, 2018).
- Experimental VP = <100 Pa at 20 °C (using isoteniscope method); not a suitable method for multi-constituents or UVCBs.
- Weighted average QSAR based VP = 0.00000187 Pa at 25°C (using EPI Suite v.4.11) and 0.000249 Pa at 25°C ( US EPA T.E.S.T. v4.2.1). The estimates for the major constituents are considered to be reliable with restrictions, as they do not completely fall within of the applicability domain.
- Experimental VP of structurally similar substance, C8-18 and C18-unsatd. DEA: 1.39 x 10-4 Pa at 20°C and 2.91 x 10-4 Pa at 25°C, respectively (ECHA REACH dossier; EC: 931-329-6).
Overall, based on the above information, the test substance can be considered to have low volatility potential. However, in absence of a specific value from the experimental study, and given that isoteniscope method is not a suitable method for determining VP values for multi-constituent or UVCB substances, the higher QSAR based VP value (i.e., 0.000249 Pa) has been considered further for hazard/risk assessment.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
