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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Well documented study report which meets basic scientific principles

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1960
Report date:
1960

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The eye irritation study in experimental animals was already performed in the 1960s. Therefore it is not conducted in accordance with the rules of Good Laboratory Practice (GLP) and internationally-agreed guidelines (e.g. OECD guideline No. 405), but using good scientific practices at that time.
BASF-Test, see details in remarks on material and methods.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
methyl 2-methylbenzene-1-sulfonate
Cas Number:
23373-38-8
Molecular formula:
C8H10O3S
IUPAC Name:
methyl 2-methylbenzene-1-sulfonate
Constituent 2
Chemical structure
Reference substance name:
Methyl toluene-4-sulphonate
EC Number:
201-283-5
EC Name:
Methyl toluene-4-sulphonate
Cas Number:
80-48-8
Molecular formula:
C8H10O3S
IUPAC Name:
methyl 4-methylbenzene-1-sulfonate
Test material form:
liquid

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
no information available.

Test system

Vehicle:
unchanged (no vehicle)
Controls:
other: The adjacent eye treated with 0.9 % NaCl (saline) served as a control.
Duration of treatment / exposure:
30 sec exposure
Observation period (in vivo):
1 week post-instillation
Number of animals or in vitro replicates:
no information available
Details on study design:
One drop of undiluted test substance was instilled into the conjunctival sac of the rabbit eye and gently spaced it out evenly onto the ocular surface. Following 10 minutes, 1, 3 and 24 hours exposure period these eyes were evaluated. Narrative description of the degree and nature of irritation or corrosion observed.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other: narrative description of the degree and nature of effects observed
Basis:
other: no data available
Time point:
other: 10 min, 1, 3 and 24 h
Score:
0
Remarks on result:
other: Significant irritation (redness and swelling of conjunctivae, cornea with diffuse areas of opacity)
Irritation parameter:
other: narrative description of the degree and nature of effects observed
Basis:
other: no data available
Time point:
other: over the course of one week
Score:
0
Reversibility:
fully reversible

Applicant's summary and conclusion

Interpretation of results:
other: irritant
Executive summary:

In a study already performed in the 1960s the undiluted test substance was irritant to the rabbit´s eye, as evidenced by reddening and swelling of the conjunctivae and diffuse areas of corneal opacity. All effects were reversible within one week after instillation of the test substance.