Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 233-634-3 | CAS number: 10287-53-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07 June 2017 to 15 November 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Version / remarks:
- 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: REACH Regulation (EU) No 1907/2006 of the European Parliament and of the Council.
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- - At each sampling time, two samples were removed from the bath and an aliquot (1 mL) of each was diluted to volume (10 mL) with mobile phase for analysis by high performance liquid chromatography (HPLC).
- Extended testing at pH 9: Duplicate samples were taken immediately to serve as t0 samples, and then several pairs of samples were analysed in the range 10 to 90 % hydrolysis to test for pseudo-first order behaviour. - Buffers:
- Buffer solutions were prepared as follows:
- pH 4: 0.2 M aqueous potassium dihydrogen orthophosphate (110 mL) was mixed with 0.07 M aqueous disodium hydrogen orthophosphate dodecahydrate (250 mL) and purified water (640 mL). The pH was adjusted to 4.0 ± 0.05 with orthophosphoric acid.
- pH 7: 0.2 M aqueous potassium dihydrogen orthophosphate (250 mL) was mixed with 1 M sodium hydroxide (30 mL) and purified water (720 mL). The pH was adjusted to 7.0 ± 0.05 with 1 M hydrochloric acid.
- pH 9: 0.1 M boric acid in 0.1 M aqueous potassium chloride (500 mL) was mixed with 1 M sodium hydroxide (21 mL) and purified water (480 mL). The pH was adjusted to 9.0 ± 0.05 with 1 M hydrochloric acid. - Details on test conditions:
- PRELIMINARY TEST
The following procedure was carried out at each of pH 4, 7 and 9:
- Aliquots (0.1 mL) of a stock solution in purified water (3 g/L) were added to separate Wheaton vials containing buffer solution (10 mL), which had been purged with nitrogen and pre-equilibrated at test temperature (50 ± 0.5 °C).
- The samples, of nominal concentration 30 mg/L, were placed in a 50 °C water bath in the dark until sampling was required (immediately, and then after 2.4, 24 and 120 hours).
- At each sampling time, two samples were removed from the bath and an aliquot (1 mL) of each was diluted to volume (10 mL) with mobile phase for analysis by high performance liquid chromatography (HPLC).
- Sample pH and incubation temperature were monitored over the period of the test.
EXTENDED TESTING AT PH 9
- Separate tests were conducted at temperatures of 50, 60 and 70 °C in the dark, and the procedure followed was as detailed for the preliminary test. Duplicate samples were taken immediately to serve as t0 samples, and then several pairs of samples were analysed in the range 10 to 90% hydrolysis to test for pseudo-first order behaviour. - Duration:
- 120 h
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 28.5 mg/L
- Duration:
- 120 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 31.7 mg/L
- Duration:
- 120 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 29.7 mg/L
- Duration:
- 480 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 31.84 mg/L
- Duration:
- 168 h
- pH:
- 9
- Temp.:
- 60 °C
- Initial conc. measured:
- 29.26 mg/L
- Duration:
- 64 h
- pH:
- 9
- Temp.:
- 70 °C
- Initial conc. measured:
- 28.91 mg/L
- Number of replicates:
- The test was performed in duplicate
- Positive controls:
- no
- Negative controls:
- no
- Preliminary study:
- - The preliminary study showed that at pH 4 and pH 7 and 50 ± 0.5 ºC, less than 10 % hydrolysis had occurred after 120 hours (5 days), equivalent to an environmental (25 °C) half-life (te½) of greater than 1 year. No further testing was therefore necessary at these pH values.
- At pH 9 and 50 ± 0.5 ºC, however, more than 10 % hydrolysis had occurred after 120 hours (5 days), indicating a te½ value of less than 1 year. This necessitated proceeding to definitive testing at this pH value. - Test performance:
- LINEARITY
Under the conditions described, the calibration of the test material was found to be linear over the range 0 to 5 mg/L with a regression coefficient of 1.0000. It was considered that the analytical method was sufficiently sensitive to quantify test material concentrations down to 10 % or less of the initial concentration.
PH OF TEST SOLUTIONS
- The results show that there were no significant changes in pH with time. - Transformation products:
- not specified
- Key result
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Remarks on result:
- hydrolytically stable based on preliminary test
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Remarks on result:
- hydrolytically stable based on preliminary test
- Key result
- pH:
- 9
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0 h-1
- DT50:
- 398 d
- Type:
- (pseudo-)first order (= half-life)
- Details on results:
- EXTENDED TESTING AT PH 9
- At pH 9, definitive tests were conducted at temperatures of 50, 60 and 70 °C, and the hydrolysis rate constant (k) and te½ at 25 °C were extrapolated from
the measured values of log10k at the selected temperatures using the Arrhenius relationship. A te½ value of 398 days was obtained at this pH value.
- The hydrolysis reactions for the test material at pH 9 were shown to follow pseudo-first order behaviour. - Validity criteria fulfilled:
- yes
- Conclusions:
- Under the conditions of this study, the test material was determined to be hydrolytically stable under acidic and neutral conditions, but to hydrolyse slowly under basic conditions with a half-life of 398 days.
- Executive summary:
The rate of hydrolysis of the test material as a function of pH was investigated in accordance with the standardised guidelines OECD 111 and EU Method C.7., under GLP conditions.
The preliminary study showed that at pH 4 and pH 7 and 50 ± 0.5 °C, less than 10 % hydrolysis had occurred after 120 hours (5 days), equivalent to an environmental (25 °C) half-life (te½) of greater than 1 year. No further testing was therefore necessary at these pH values.
At pH 9 and 50 ± 0.5 °C, however, more than 10 % hydrolysis had occurred after 120 hours (5 days), indicating a te½ value of less than 1 year. This necessitated proceeding to definitive testing at this pH value.
The hydrolysis reactions for the test material were shown to follow pseudo-first order behaviour in definitive testing at pH 9. Definitive tests were conducted at temperatures of 50, 60 and 70 °C, and the hydrolysis rate constant (k) and te½ at 25 °C were extrapolated from the measured values of log10k at the selected temperatures using the Arrhenius relationship. A te½ value of 398 days was obtained at pH 9.
Under the conditions of this study, the test material was determined to be hydrolytically stable under acidic and neutral conditions, but to hydrolyse slowly under basic conditions with a half-life of 398 days.
Reference
Table 1: Preliminary test results for hydrolysis of the test material
pH |
Concentration of the test material in solution at time th (in hours) (mg/L) |
|||||||
t0h |
t2.4h |
t24h |
t120h |
|||||
Measured |
Mean |
Measured |
Mean |
Measured |
Mean |
Measured |
Mean |
|
4 |
28.7, 28.3 |
28.5 |
29.3, 29.3 |
29.3 |
28.2, 28.1 |
28.2 |
28.8, 28.9 |
28.8 |
7 |
32.2, 31.3 |
31.7 |
31.5, 31.5 |
31.5 |
30.6, 30.8 |
30.7 |
30.5, 31.1 |
30.8 |
9 |
28.9, 30.6 |
29.7 |
30.7, 30.4 |
30.5 |
30.4, 29.7 |
30.1 |
23.8, 24.1 |
23.9 |
Table 2: Results for hydrolysis of the test material at pH 9 and 50 °C
Time (hours) |
Concentration (mg/L) |
Mean concentration (mg/L) |
log10Ct |
0 |
31.93, 31.74 |
31.84 |
1.503 |
72 |
28.84, 28.60 |
28.72 |
1.458 |
144 |
25.57, 25.56 |
25.57 |
1.408 |
216 |
22.23, 23.18 |
22.71 |
1.356 |
336 |
18.20, 18.36 |
18.28 |
1.262 |
408 |
16.30, 17.04 |
16.67 |
1.222 |
480 |
14.83, 15.25 |
15.04 |
1.177 |
Exponential regression, log10Ct= 1.505 - 0.00069t
r = -0.9992
rate constant, kobs= -slope x 2.303 = 0.001598 hour-1
Table 3: Results for hydrolysis of the test material at pH 9 and 60 °C
Time (hours) |
Concentration (mg/L) |
Mean concentration (mg/L) |
log10Ct |
0 |
29.54, 28.97 |
29.26 |
1.466 |
24 |
25.95, 25.93 |
25.94 |
1.414 |
48 |
22.28, 22.86 |
22.57 |
1.354 |
72 |
20.34, 21.18 |
20.76 |
1.317 |
120 |
16.68, 16.39 |
16.54 |
1.218 |
144 |
14.86, 15.37 |
15.12 |
1.179 |
168 |
13.51, 13.45 |
13.48 |
1.130 |
Exponential regression, log10Ct= 1.459 - 0.00197t
r = -0.9989
Rate constant, kobs= -slope x 2.303 = 0.004548 hour-1
Table 4: Results for hydrolysis of the test material at pH 9 and 70 °C
Time (hours) |
Concentration (mg/L) |
Mean concentration (mg/L) |
log10Ct |
0 |
28.79, 29.02 |
28.91 |
1.461 |
7 |
25.98, 26.26 |
26.12 |
1.417 |
16 |
20.96, 20.97 |
20.97 |
1.321 |
31 |
18.76, 18.91 |
18.84 |
1.275 |
40 |
15.19, 15.09 |
15.14 |
1.180 |
55 |
12.60, 13.23 |
12.92 |
1.111 |
64 |
12.58, 12.35 |
12.47 |
1.096 |
Exponential regression, log10Ct= 1.445 - 0.00588t
r = -0.9872
Rate constant, kobs= -slope x 2.303 = 0.01354 hour-1
Description of key information
The rate of hydrolysis of the test material as a function of pH was investigated in accordance with the standardised guidelines OECD 111 and EU Method C.7., under GLP conditions.
The preliminary study showed that at pH 4 and pH 7 and 50 ± 0.5 °C, less than 10 % hydrolysis had occurred after 120 hours (5 days), equivalent to an environmental (25 °C) half-life (te½) of greater than 1 year. No further testing was therefore necessary at these pH values.
At pH 9 and 50 ± 0.5 °C, however, more than 10 % hydrolysis had occurred after 120 hours (5 days), indicating a te½ value of less than 1 year. This necessitated proceeding to definitive testing at this pH value.
The hydrolysis reactions for the test material were shown to follow pseudo-first order behaviour in definitive testing at pH 9. Definitive tests were conducted at temperatures of 50, 60 and 70 °C, and the hydrolysis rate constant (k) and te½ at 25 °C were extrapolated from the measured values of log10k at the selected temperatures using the Arrhenius relationship. A te½ value of 398 days was obtained at pH 9.
Under the conditions of this study, the test material was determined to be hydrolytically stable under acidic and neutral conditions, but to hydrolyse slowly under basic conditions with a half-life of 398 days.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 398 d
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.