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Diss Factsheets
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EC number: 451-160-7 | CAS number: 17913-76-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: according to EC Directive 92/69/EEC and Regulation EC/440/2008 guideline methods under GLP conditions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- Deviations:
- no
- GLP compliance:
- yes
- Details on sampling:
- At the end of the 3 hour incubation, a portion of the first test mixture was transferred to
fill a clean 250 mL (nominal volume) sample bottle containing a PTFE-coated stirrer bar.
The DO probe was inserted in the sample bottle, taking care to avoid trapping air bubbles
against the probe membrane. The probe was sealed against the bottle-neck to ensure that
the sample could not become re-oxygenated by contact with the atmosphere. - Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Details on inoculum:
- Preparation and Maintenance of the Inoculum
The inocula used in this study were not acclimatised or adapted to the test item before exposure to the test substance under test conditions. The inocula were maintained by aeration at all times and were fed overnight with synthetic sewage at a rate of 50 mL/L during the intervals between preparation and final use. - Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 3 h
- Test temperature:
- 21 °C
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Details on results:
- In the definitive (limit) test five replicates were employed, each containing the test item at a concentration of 1000 mg/L. The purpose of this test was firstly to assess the reproducibility with a greater number of replicates, and secondly to show that the EC50 of the test substance was less than 1000 mg/L. The results of the definitive (limit) assessment are presented in Table 3.
As in previous tests, the reproducibility was poor with results ranging from 26 % enhancement to 47% inhibition. The maximum level of inhibition observed was 47%, therefore based on the results of this test, it is concluded that the EC50 of 2,4,7,9-tetramethyldecane-4,7-diol is greater than 1000 mg/L. - Results with reference substance (positive control):
- The EC50 for 3,5-DCP was estimated from a plot of the results to be 5.92 mg/L.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 3-hour EC50 for sludge respiration inhibition by 2,4,7,9-tetramethyldecane-4,7-diol is greater than 1000 mg/L.
- Executive summary:
The 3-hour EC50 for sludge respiration inhibition by 2,4,7,9-tetramethyldecane-4,7-diol is greater than 1000 mg/L.
Reference
Description of key information
The 3-hour EC50 for sludge respiration inhibition by 2,4,7,9-tetramethyldecane-4,7 -diol is greater than 1000 mg/L.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 1 000 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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