Registration Dossier
Registration Dossier
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EC number: 459-990-1 | CAS number: 52411-34-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 92/69/EWG, B.3
- GLP compliance:
- yes
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 459-990-1
- EC Name:
- -
- Cas Number:
- 52411-34-4
- Molecular formula:
- Hill formula: C14H16N2O2 CAS formula: C14H16N2O2
- IUPAC Name:
- 1,2-Bis(2-aminophenoxy)ethane
Constituent 1
Test animals
- Species:
- other: rat, Sprague-Dawley Hsd:(SD)
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: Angeteigt mit 0,3 ml Tylose (0,5 % in Wasser) "ENGLISH" Made into a paste with 0.3 ml tylose (0.5 % in water)
- Duration of exposure:
- 24 h
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- Signs of toxicity related to dose levels:
Während der gesamten Studiendauer traten weder Todesfälle
noch sonstige Effekte auf. Bei einem weiblichen Tier war das
Körpergewicht in der ersten Woche leicht reduziert, am Ende
der Studie war das Gewicht jedoch wieder normal.
Die Körpergewichtsentwicklung der übrigen Tiere war nicht
beeinflusst.
"ENGLISH"
Neither mortalities nor other effects occurred during the
entire duration of the study. The body weight of one female
animal was slightly reduced in the first week. However, the
weight was normal again at the end of the study.
The body-weight gain of the other animals was not
influenced. - Gross pathology:
- Effects on organs:
Bei der Sektion der Tiere wurden keine makroskopisch
sichtbaren Effekte festgestellt.
"ENGLISH"
No macroscopically visible effects were determined during
the necropsy of the animals. - Other findings:
- Signs of toxicity (local):
Es wurde keine Reizung festgestellt.
"ENGLISH"
No irritation was determined.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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