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EC number: 294-589-3 | CAS number: 91744-27-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The substance is not considered to be irritating to the skin or eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In vivo skin irritation (OECD 404)
In a GLP compliant in vivo skin irritation study, performed according to OECD 404, 3 Kleinrussen Chbb:HM rabbits received a dermal application of the undiluted test substance. The animals were exposed for 4 hours under semi-occlusive conditions. Erythema and oedema were scored after 1, 24, 48 and 72 hours. The reversibility of the reactions was recorded for 7 days. The mean (24-72 h) erythema score was determined to be 0.66, 1.66, and 0 for animal 1, 2, and 3, respectively. The mean (24-72h) oedema score was determined to be 0, 1, and 0 for animal 1, 2, and 3, respectively. All observations were reversible within 7 days. Based on these observations, the substance was not considered to be irritating to the skin (Henkel, 1990).
In vivo eye irritation (OECD 405)
In a GLP compliant in vivo eye irritation study, performed according to OECD 405, 0.1 mL undiluted test substance was applied to the right eye of three Kleinrussen, Chbb:HM rabbits. Directly after application the eyelids were shortly closed. After an exposure period of 24 hours, the eye was thoroughly washed with warm water to terminate the exposure. The left eye served as a negative (untreated) control. Reactions were scored after 1, 24, 48 and 72 hours and 7 and 14 days. At the 24 hour and 7 day timepoints, the eye was treated with fluorescein and examined by means of a split lamp. In one animal a very slight corneal lesion was observed. Based on the fluorescein staining on day 14 however, a substance specific effect could be excluded. Other effects were limited to exudation (1 hour after treatment in all animals) and chemosis (only 1 hour after treatment in 1 animal). The average cornea score (24-72h) was determined to be 1 for 1 animal. For other 2 animals this score was determined to be 0. All other average (24-72 h) scores (iris, conjunctivae, chemosis) were determined to be 0 for all animals. Based on these data, the substance is not considered to be an eye irritant (Henkel, 1990).
Justification for classification or non-classification
Based on the available data classification and labelling for skin and eye irritation is not warranted in accordance with EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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