Registration Dossier
Registration Dossier
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EC number: 216-652-6 | CAS number: 1634-02-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU method B.47 (Bovine corneal opacity and permeability test method for identifying ocular corrosives and severe irritants)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Tetrabutylthioperoxydicarbamic acid
- EC Number:
- 216-652-6
- EC Name:
- Tetrabutylthioperoxydicarbamic acid
- Cas Number:
- 1634-02-2
- Molecular formula:
- C18H36N2S4
- IUPAC Name:
- tetrabutylthioperoxydicarbamic acid
- Test material form:
- liquid
Constituent 1
Test animals / tissue source
- Species:
- cattle
Test system
- Vehicle:
- Hank's balanced salt solution
- Controls:
- yes, concurrent positive control
- yes, concurrent negative control
- Amount / concentration applied:
- 0.75mL applied
- Duration of treatment / exposure:
- 10 minutes exposure then rinsed 3 times
- Duration of post- treatment incubation (in vitro):
- 120 minutes
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vitro
Results
- Irritation parameter:
- in vitro irritation score
- Value:
- >= 2.1
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Any other information on results incl. tables
| Treatment | In Vitro Irritancy Score |
| Test Item | 2.1 |
| Negative Control | 1.0 |
| Positive Control | 57.9 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No evidence of eye irritancy.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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