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Diss Factsheets
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EC number: 241-143-0 | CAS number: 17084-13-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- unknown
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Screening of Fluorine-Containing Compounds for Acute Toxicity
- Author:
- Smith FA, Downs WL, Hodge HC, Maynard EA
- Year:
- 1 960
- Bibliographic source:
- Toxicology and Applied Pharmacology 2, 54-58
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Principle of test: similar to up- and down-procedure
- Short description of test conditions: Graded series of doses were administered starting with a unit of 1 (mL, mg, g) and progressing upward or downward as determined by the results, using a factor of 3/2 if the dose was tolerated or 2/3 if the dose proved fatal.
- Parameters analysed / observed: mortality - GLP compliance:
- no
Test material
- Reference substance name:
- Potassium hexafluorophosphate
- EC Number:
- 241-143-0
- EC Name:
- Potassium hexafluorophosphate
- Cas Number:
- 17084-13-8
- Molecular formula:
- F6P.K
- IUPAC Name:
- potassium hexafluoro-λ⁵-phosphanuide
Constituent 1
- Specific details on test material used for the study:
- no specific details given
Test animals
- Species:
- mouse
- Strain:
- other: albino mice
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- - Weight at study initiation: 20-30 g
- no further details given
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: either water, corn oil or propylene glycol; not precisely specified for the target compound
- Details on exposure:
- not reported
- Doses:
- Graded series of doses were administered starting with a unit of 1 (mL, mg, g) and progressing upward or downward as determined by the results, using a factor of 3/2 if the dose was tolerated or 2/3 if the dose proved fatal.
- No. of animals per sex per dose:
- 2
- Control animals:
- not specified
- Details on study design:
- not described
- Statistics:
- not described
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- female
- Dose descriptor:
- other: maximal non-lethal dose
- Effect level:
- ca. 960 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- female
- Dose descriptor:
- other: minimal lethal dose
- Effect level:
- ca. 1 120 mg/kg bw
- Based on:
- test mat.
- Mortality:
- At the minimal lethal dose of 1120 mg/kg bw, the two animals tested had died after 24 h.
- Clinical signs:
- not reported
- Body weight:
- not reported
- Gross pathology:
- not reported
- Other findings:
- not reported
Applicant's summary and conclusion
- Conclusions:
- The maximal non-lethal dose was determined to be in the range of 960 mg/kg bw and the minimal lethal dose in the range of 1120 mg/kg bw.
- Executive summary:
In a toxicity study published by Smith et al. (1960), each two female albino mice were given potassium hexafluorophosphate intraperitoneally in a method using graded series of doses and observed for 24 h.
Hardly any details on experimental conditions are reported and the respective reference was not available. Thus, reliability was rated 4.
Maximal non-lethal dose= 960 mg/kg bw
Minimal lethal dose= 1120 mg/kg bw
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