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EC number: 239-717-0 | CAS number: 15647-11-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1980-11
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with national standard methods
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- Method: other: Draize Test according to Consumer Product Safety Commission (U.S.), Code of Federal Regulations, Title 16, Section 1500.42;
Evaluation with Draize scores - GLP compliance:
- no
Test material
- Reference substance name:
- 3-aminomethyl-3,5,5-trimethylcyclohexan-1-ol
- EC Number:
- 239-717-0
- EC Name:
- 3-aminomethyl-3,5,5-trimethylcyclohexan-1-ol
- Cas Number:
- 15647-11-7
- Molecular formula:
- C10H21NO
- IUPAC Name:
- 3-(aminomethyl)-3,5,5-trimethylcyclohexan-1-ol
- Test material form:
- liquid: viscous
- Details on test material:
- 3-aminomethyl-3,5,5-trimethylcyclohexan-1-ol
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS:
- Strain: New Zealand white
- Source: J. Scheele, Büderich/Westf., 4760 Werl
Housing conditions:
- Room temperature: 20°C (+/- 1°C);
- Light: 12 hours/day;
- Access to drinking water: ad libitum;
- Diet: K4 diet for rabbits (Ssniff; Soest)
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- undiluted
Amount applied: 0.1 ml - Duration of treatment / exposure:
- not rinsed
no removal of test substance - Observation period (in vivo):
- Ophthalmoscopic examination after 24, 48, 72 hours
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- Tool used to assess score: sodium fluorescein / ophthalmic lamp / visual inspections
Scoring system: Draize (1959)
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Very strong reactions after 24h observation so that all animals were killed
- Remarks:
- Based on very strong reactions a score could not determined.
- Time point:
- 24 h
- Score:
- 20
- Max. score:
- 20
- Reversibility:
- not reversible
- Remarks on result:
- probability of severe irritation
Any other information on results incl. tables
no further remarks
Applicant's summary and conclusion
- Conclusions:
- Under conditions of the study test item showed necrosis effects to rabbit eyes. Due to the severe damage of the eyes, rabbits were euthanized 24 after application.
- Executive summary:
The acute eye irritation properties of the test item were estimated in a Draize test. An amount of 0.1 ml of the undiluted test substance was instilled into one eye of each of six albino rabbits, and the untreated eye served as control. The eyes are not washed following instillation of test material.
24 hours after application all animals showed necrosis effects on the eyes. Due to the severe damage of the eyes, rabbits were euthanized 24 after application.
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