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Diss Factsheets
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EC number: 203-430-9 | CAS number: 106-75-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Study of Industrial Bio-Test Laboratories (IBT).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- only 2 animal/sex and dose
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Oxydiethylene bis(chloroformate)
- EC Number:
- 203-430-9
- EC Name:
- Oxydiethylene bis(chloroformate)
- Cas Number:
- 106-75-2
- Molecular formula:
- C6H8Cl2O5
- IUPAC Name:
- oxydiethane-2,1-diyl dichlorocarbonate
- Details on test material:
- Purity of the test material was not indicated
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.44 - 2.90 kg
- food and water: ad libidum
- Acclimation period: at least 7 days
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 h
- Doses:
- 2.0, 3.0, 4.6, 6.8 g/kg bw
- No. of animals per sex per dose:
- 2
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: weighing prior to treatment and at 14 days (if still alive)
- Necropsy of survivors performed: on day 14
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 3 400 mg/kg bw
- Mortality:
- None of the animals treated with 2.0 g/kg died, but all weighed less at 14 days than at the beginning of the study. The two males treated with 3.0 g/kgand two males and 1 female treated with 4.6 g/kg died within 3 days oftreatment. Whereas the survivors treated with 3.0 mg/kg gained a slight amount of weight (50-100 g) over the 14 day observation period, the survivor treated with 4.6 mg/kg lost a slight amount of weight (80 g). All animals treated with 6.8 mg/kg died within 2 days of treatment.
- Clinical signs:
- No untoward behavioral reactions were noted. Pale red to red, well-defined erythema, moderate edema and burns were noted at the test site after 24 hours. Superficial escharosis was noted 6 days after treatment. The skin began to slough at 14 days
- Body weight:
- None of the animals treated with 2.0 g/kg died, but all weighed less at 14 days than at the beginning of the study. The two males treated with 3.0 g/kgand two males and 1 female treated with 4.6 g/kg died within 3 days oftreatment. Whereas the survivors treated with 3.0 mg/kg gained a slight amount of weight (50-100 g) over the 14 day observation period, the survivor treated with 4.6 mg/kg lost a slight amount of weight (80 g). All animals treated with 6.8 mg/kg died within 2 days of treatment.
- Gross pathology:
- No gross pathologic alterations other than the dermal alterations.
Any other information on results incl. tables
None of the animals treated with 2.0 g/kg died, but all weighed less at 14 days than at the beginning of the study. The two males treated with 3.0 g/kg and two males and 1 female treated with 4.6 g/kg died within 3 days of treatment. Whereas the survivors treated with 3.0 mg/kg gained a slight amount of weight (50-100 g) over the 14 day observation period, the survivor treated with 4.6 mg/kg lost a slight amount of weight (80 g). All animals treated with 6.8 mg/kg died within 2 days of treatment.
No untoward behavioral reactions were noted. Pale red to red, well-defined erythema, moderate edema and burns were noted at the test site after 24 hours. Superficial escharosis was noted 6 days after treatment. The skin began to slough at 14 days. Necropsies of all animals did not reveal any gross pathologic alterations other than the dermal alterations.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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