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Diss Factsheets
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EC number: 247-092-0 | CAS number: 25549-16-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Triisooctylamine
- EC Number:
- 247-092-0
- EC Name:
- Triisooctylamine
- Cas Number:
- 25549-16-0
- Molecular formula:
- C24H51N
- IUPAC Name:
- tris(6-methylheptyl)amine
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Lot/batch No.: 0008924462
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Wiga GmbH, Germany
- Age at study initiation: female animals approx. 10 weeks
- Weight at study initiation: animals of comparable size and weight
- Fasting period before study: Feed was withdrawn from the animals at least 16 hours before administration, but water was available ad libitum.
- Housing: Single housing
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22°C +- 3
- Humidity (%): 30 – 70
- Air changes (per hr): ca. 10
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: unchanged (no vehicle) or corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: only for 300 mg/kg: 15 g/100 mL
- Amount of vehicle (if gavage): 2 mL/kg bw
- Justification for choice of vehicle: corn oil was a suitable vehicle
MAXIMUM DOSE VOLUME APPLIED: 2.47 mL/kg bw (undiluted) or 2 mL/kg (300 mg/kg) - Doses:
- 300 and 2000 mg/kg
- No. of animals per sex per dose:
- 3 females at 2000 mg/kg and 6 females at 300 mg/kg
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: A check for any dead or moribund animals was made at least once each workday. Clinical signs for each animal were recorded several times on the day of administration and at least once during each workday thereafter. Individual body weights shortly before administration (day 0), weekly thereafter and on the day of death or sacrifice moribund starting with study day 6.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, necropsy with gross-pathology examination was performed on the last day of the observation period after sacrifice by CO2-inhalation in a chamber with gradually increasing concentrations. Necropsy of all animals that died as early as possible after death. - Statistics:
- N/A
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 300 - < 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- One animal of the 2000 mg/kg bw test group was found dead on study day 6 (delayed mortality), while the two remaining animals were sacrificed in a moribund state on the same day. No mortality occurred in both 300 mg/kg bw test groups.
- Clinical signs:
- other: In the animal of the 2000 mg/kg bw test group that was found dead on study day 6 impaired general state and piloerection were observed from study day 1 until study day 3, while exsiccosis and body weight reduction were noted from study day 2 until study d
- Gross pathology:
- Due toe the advanced putrefaction no macroscopic pathological findings could be determined in the animal that was found dead on study day 6. In the animals which were sacrificed in a moribund state on study day 6 no macroscopic pathological findings were observed. There were no macroscopic pathological findings in the animals sacrificed at the end of the observation period (300 mg/kg bw: 6 females).
Any other information on results incl. tables
Under the conditions of this study the median lethal dose of Triisooctylamine after oral administration was found to be greater than 300 mg/kg bw and less than 2000 mg/kg bw in rats.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
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