Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 259-653-7 | CAS number: 55466-76-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09-Nov-1995 to 12-Nov-1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study (OECD 404)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- (occlusive)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- (occlusive)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Hexakis[μ-(acetato-O:O')]-μ3-oxo-triangulo-triruthenium acetate
- EC Number:
- 259-653-7
- EC Name:
- Hexakis[μ-(acetato-O:O')]-μ3-oxo-triangulo-triruthenium acetate
- Cas Number:
- 55466-76-7
- Molecular formula:
- C12H18O13Ru3.C2H3O2
- IUPAC Name:
- hexamethyl-2λ³-oxa-4λ³-oxa-6λ³-oxa-8λ³-oxa-10λ³-oxa-12λ³-oxa-13λ³-oxa-15λ³-oxa-16λ³-oxa-18λ³-oxa-19λ³-oxa-21λ³,22λ¹-dioxa-1,5,9-triruthenahexacyclo[7.3.3.3¹,⁵.3⁵,⁹.1¹,⁵.0⁹,²²]docosa-3,7,11,14,17,20-hexaene-1,1,1,5,5,5,9,9,9-nonakis(ylium)-2,6,10,13,16,19-hexaide-22,22-diuide acetate
- Details on test material:
- - Name of test material (as cited in study report): ruthenium acetate
- Substance type: black crystalline solid
- Physical state: solid
- Analytical purity: not stated
- Impurities (identity and concentrations): not stated
- Composition of test material, percentage of components: not stated
- Isomers composition: not stated
- Purity test date: not stated
- Lot/batch No.: 60350
- Expiration date of the lot/batch: not stated
- Stability under test conditions: not stated
- Storage condition of test material: room temperature
- Other:
- Date received: 23-Oct-1995
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: David Percival Ltd., Moston, Sandbach, Cheshire, UK
- Age at study initiation: 12-16 weeks
- Weight at study initiation: 2.38-2.48 kg
- Housing: individually in suspended metal cages
- Diet (e.g. ad libitum): Stanrab SQC rabbit diet, ad libitum
- Water (e.g. ad libitum): mains drinking water, ad libitum
- Acclimation period: >=5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17-18
- Humidity (%): 56-65
- Air changes (per hr): ~15
- Photoperiod (hrs dark / hrs light): 12 / 12
IN-LIFE DATES: From: 09-Nov-1995 To: 12-Nov-1995
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped
- Vehicle:
- water
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g
- Concentration (if solution): not applicable, crystalline solid moistened with water
VEHICLE
- Amount(s) applied (volume or weight with unit): 0.5 ml
- Concentration (if solution): not applicable, solid test material moistened with water
- Lot/batch no. (if required): not applicable
- Purity: not stated, distilled water - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- 3
- Details on study design:
TEST SITE
- Area of exposure: 6.25 cm2
- % coverage: not stated
- Type of wrap if used: cotton gauze patch (2.5 cm x 2.5 cm) secured with Blenderm (2.5 cm x 4.0 cm) (note: this is an occlusive tape), trunk wrapped in an elasticated Tubigrip corset
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes, gentle swabbing with cotton wool soaked in distilled water, followed by 74% Industrial Methylated Spirits
- Time after start of exposure: 4 hours
SCORING SYSTEM: Draize (erythema and eschar 0-4, oedema 0-4; primary irritation index calculated as total of scores for both endpoints, for both timepoints, for all 3 rabbits (12 values) divided by 6; classification according to Draize scheme)
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24- and 72-hour timepoints combined
- Score:
- 0
- Max. score:
- 8
- Reversibility:
- other: not applicable
- Irritant / corrosive response data:
- No skin reactions (erythema or oedema) were seen at any timepoint (1, 24, 48 and 72 hours after removal of patches) in any of the 3 test animals; scores of 0.0 were recorded on each occasion giving a primary irritation index of 0.0
- Other effects:
- Faint green/black staining at all treatments sites
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In a guideline study, to GLP, no irritation potential was observed when ruthenium acetate was applied (under occlusion for 4 hr) to the clipped, intact skin of three rabbits.
- Executive summary:
In an OECD Test Guideline 404 study, conducted according to GLP, ruthenium acetate (0.5 g, moistened with 0.5 mL water) was applied (occluded) to the clipped intact skin of 3 New Zealand White rabbits. After 4 hours, the dressings were removed and the treated skin sites were washed and subsequently observed for erythema and oedema 1, 24, 48 and 72 hours.
No skin reactions were recorded at any time point in any animal during the 72-hr observation period. The primary dermal irritation index was therefore 0, and ruthenium acetate was classified as a non-irritant to rabbit skin under the conditions of the test.
No skin classification, according to EU CLP criteria (EC 1272/2008), is required on the basis of this study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.