Manganese bis(phosphinate)

Toxicity to aquatic algae and cyanobacteria

Link to relevant study record(s)

Reference

Endpoint:

toxicity to aquatic algae and cyanobacteria

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data for the target chemical is summarized based on the structurally similar read across chemicals.

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

Acute toxicity test was carried out for 72 hr to study the effects of test chemical on aquatic algae.

GLP compliance:

not specified

Analytical monitoring:

not specified

Vehicle:

not specified

Test organisms (species):

Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)

Test type:

static

Water media type:

freshwater

Total exposure duration:

72 h

pH:

2. 5.61 and 3.4

Duration:

72 h

Dose descriptor:

EC50

Effect conc.:

> 100 mg/L

Nominal / measured:

meas. (not specified)

Conc. based on:

test mat.

Basis for effect:

growth rate

Remarks on result:

other: read across 1

Duration:

72 h

Dose descriptor:

EC50

Effect conc.:

77.9 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth rate

Remarks on result:

other: read across 2

Details on results:

1. After 72 hours of exposure no effects was observed
2. No abnomalities were detected in any of the cultures and there was no sign of contamination by foreign algal cells or protozoa.

Conclusions:

The test chemical manganese(2+) bis(phosphinate) is not likely to be toxic to aquatic algae atleast in the dose range of 77.9->100 mg/l.

Executive summary:

Following studies of structurally andfunctionallysimilar read across has ben assessed to conclude the toxicity extent of manganese(2+) bis(phosphinate) (CAS: 10043-84-2) towards aquatic algae is summarized as follows:

Experimental study 1 suggests that the 72 hr-EC50 of test chemical to Selenastrum capricornutum was more than 100 mg/L. After 72 hours of exposure no effects was observed. It can be concluded from the growth rate value that the test chemical is not toxic aquatic algaeand can be considered as “not classified” as per the classification criteria for aquatic environment.

Similar supporting study 2 also suggesting that the Acute toxicity test was carried out for 72 hr to study the effects of test chemical on aquatic algae. The 72hr-EC50 values expressed in terms of the mean measured concentration of test chemical to Pseudokirchneriella subcapitata. No abnomalities were detected in any of the cultures and there was no sign of contamination by foreign algal cells or protozoa.

Thus based on the effect concentrations of structurally andfunctionallysimilar read across it gives the conclusion that test substance

manganese(2+) bis(phosphinate) (CAS: 10043-84-2) is likely to be not toxic to aquatic environment at environmentally relevant concentrations and applying weight of evidence approach it can be considered to be “not classified” as per the CLP classification criteria.

Description of key information

72 hr-EC50 of test chemical to Selenastrum capricornutum was more than 100 mg/L. After 72 hours of exposure no effects was observed. It can be concluded from the growth rate value that the test chemical is not toxic aquatic algaeand can be considered as “not classified” as per the classification criteria for aquatic environment.

Key value for chemical safety assessment

EC50 for freshwater algae:

100 mg/L

Additional information

Following studies of structurally and functionally similar read across has ben assessed to conclude the toxicity extent of manganese(2+) bis(phosphinate) (CAS: 10043-84-2) towards aquatic algae is summarized as follows:

Experimental study 1 suggests that the 72 hr-EC50 of test chemical to Selenastrum capricornutum was more than 100 mg/L. After 72 hours of exposure no effects was observed. It can be concluded from the growth rate value that the test chemical is not toxic aquatic algaeand can be considered as “not classified” as per the classification criteria for aquatic environment.

Similar supporting study 2 also suggesting that the Acute toxicity test was carried out for 72 hr to study the effects of test chemical on aquatic algae. The 72hr-EC50 values expressed in terms of the mean measured concentration of test chemical to Pseudokirchneriella subcapitata. No abnomalities were detected in any of the cultures and there was no sign of contamination by foreign algal cells or protozoa.

Thus based on the effect concentrations of structurally andfunctionallysimilar read across it gives the conclusion that test substance

manganese(2+) bis(phosphinate) (CAS: 10043-84-2) is likely to be not toxic to aquatic environment at environmentally relevant concentrations and applying weight of evidence approach it can be considered to be “not classified” as per the CLP classification criteria.