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Diss Factsheets
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EC number: 207-012-7 | CAS number: 422-05-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 15 Jun - 12 Nov 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Non-GLP, the study was conducted according to the old test guidance. The basic data are given, but not the detailed BCF relevant determinations according to the current standard, e.g.no study of steady state, no lipid corrections, etc.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: Circular on Test Methods of New Chemical Substances (Japan), Bioaccumulation test in fish
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 305 (Bioconcentration: Flow-through Fish Test)
- Deviations:
- no
- Remarks:
- Comply with the standard at the time of testing
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,2,3,3,3-pentafluoropropanol
- EC Number:
- 207-012-7
- EC Name:
- 2,2,3,3,3-pentafluoropropanol
- Cas Number:
- 422-05-9
- Molecular formula:
- C3H3F5O
- IUPAC Name:
- 2,2,3,3,3-Pentafluoropropan-1-ol
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Daikin Industries, Ltd.
- Expiration date of the lot/batch: no data
- Purity test date: 99.4%
Sponsors's data on the test material:
- State: clourless liquid
- BP: 80.3°C
- Density: 1.54 (25°C)
- Solubility in Water: > 2000 ppm - Radiolabelling:
- no
Sampling and analysis
- Details on sampling:
- - Sampling intervals/frequency for test organisms: Took two fish of each test concentration for analtic at Week 2, 4, 6 and 8
- Sampling intervals/frequency for test medium samples: Took 25 mL test medium for concentrations determination at Day 2, 5, 10, 12, 16, 19, 23, 26, 30, 33, 38, 40, 44, 47, 51 and 54
- Sample storage conditions before analysis: no storage
- Details on sampling and analysis of test organisms and test media samples (e.g. sample preparation, analytical methods):
- 2 fish were sampled during the uptake phase. After measurement of weight and length, fish was freeze-dried, minced, dissolved in dechlorinated water, urea added, distillated and dissolved in diethyl ether. Sodium chloride was added in diethyl ether layer. After repeated washing with diethyl ether, diethyl ether layer was filtered for dewatering for GC-MS sample.
- After sampling of the test water, sodium chloride was added. After washing with diethyl ether, the diethyl ether layer was filtered for dewatering and concentrated for GC-MS sample.
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- TEST ORGANISM
- Common name: Carp
- Length at study initiation (length definition, mean, range and SD): average length 10,2 cm
- Weight at study initiation (mean and range, SD): average length weiight 30,6 g
- Lipid content at test initiation (mean and range, SD): average lipid content 4.1%
Maitain:
- External disinfection: pretreament in 10 ppm HCl for 24 hours
ACCLIMATION
- Acclimation period: 14 d
- Acclimation conditions (same as test or not): 25°C
Study design
- Route of exposure:
- aqueous
- Test type:
- flow-through
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 8 wk
- Total depuration duration:
- 0 d
Test conditions
- Hardness:
- no data
- Test temperature:
- 25 ± 1 °C
- pH:
- no data
- Dissolved oxygen:
- no data
- TOC:
- no data
- Salinity:
- no data
- Conductivity:
- no data
- Details on test conditions:
- TEST SYSTEM
- Test vessel: Test vessel for bioaccumulation test of volatile chemical substances
- Material, size, headspace, fill volume: glass, 100 L
- Type of flow-through (e.g. peristaltic or proportional diluter): propotional diluter: 2 mL/min (stock solution) : 800 mL/min (dilution water)
- Renewal rate of test solution (frequency/flow rate): 1125 L/d
- No. of organisms per vessel: 8 in each concentration
- No. of vessels per concentration (replicates): 1
RANGE-FINDING / PRELIMINARY STUDY
- Test concentrations: According to the TLm test, 240, 320, 420, 560, 750 and 1000 ppm was tested in Medaka fish.
- Results used to determine the conditions for the definitive study: TLm value for 48 h: 450 ppm (W/V) - Nominal and measured concentrations:
- Nominal concentration: 1 and 0.1 ppm (W/V)
Mesured concentration: 868 ppb, 876 ppb, 864 ppb and 856 ppb, and 79.3, 91.2, 86,7. and 86.0 ppb at week 2, 4, 6 and 8, respectively - Reference substance (positive control):
- no
Results and discussion
Depuration
- Elimination:
- no
- Remarks on result:
- not measured/tested
- Details on results:
- - Mortality of test organisms: no mortality
- Behavioural abnormalities: no adverse effects were observed
Any other information on results incl. tables
Table 1. Accumulation ratio of the test substance
Nominal concentration |
2 W |
4 W |
6 W |
8 W |
1 ppm |
(0.9)* (0.8) |
<= 0.2 (0.8) |
(0.4) (0.5) |
(0.7) (0.7) |
0.1 ppm |
<= 2.3 <= 2.3 |
<= 2.3 <= 2.3 |
<= 2.3 <= 2.3 |
<= 2.3 <= 2.3 |
( )*: as reference value (see Table 2)
Table 2. The value range with reliable values, range for reference data, and range under detection limit
|
Fish concentration |
Accumulated ratio |
Range with reliable value |
<= 4.9 |
(1 ppm) >= 5.7 (0.1 ppm) >= 5.7 |
Range for reference values |
0.2 – 4.9 |
(1 ppm) 0.2 - 5.7 (0.1 ppm) 2.3 – 5.7 |
Under detection limit |
<= 0.2 |
(1 ppm) <= 0.2 (0.1 ppm) <= 2.3 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.