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Diss Factsheets
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EC number: 233-465-5 | CAS number: 10191-18-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From November 21, 2017 to January 19, 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, adapted
- Details on inoculum:
- - Source of activated sludge: Joint Abbotsford Mission Environmental System (JAMES) wastewater treatment plant, Abbotsford, BC.
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 65.3 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- - Test temperature: 20°C
- Suspended solids concentration: ~20 mg/L - Reference substance:
- benzoic acid, sodium salt
- Remarks:
- Sodium benzoate (CAS No. 532-32-1)
- Parameter:
- % degradation (O2 consumption)
- Remarks on result:
- other: I850 cannot be considered readily biodegradable under the test conditions as I850 did not enter the 10 day window and a result did not surpass 60% biodegradation by the end of the 10-day window.
- Results with reference substance:
- At Test completion (Day 28), the biodegradation was 76%.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- According to OECD 301F test method, I850 was not be considered readily biodegradable.
- Executive summary:
This test using the procedures outlined in the Maxxam Study Plan for TOX1739 which is based on the SOP for the OECD 301F (BBY2 SOP-00023) and OECD 301F (OECD, 1992). The results of this OECD 301F test for I850 show that all validity criteria were met. I850 cannot be considered readily biodegradable under the test conditions as I850 did not enter the 10 day window and a result did not surpass 60% biodegradation by the end of the 10-day window. Due to the stringency of this test, test items which do not achieve pass levels may still be biodegradable in the environment.
Reference
At the end of the test, the difference between replicates was 13%. At Day 14 during the study, the biodegradation of the Reference Item was 74% and the percent biodegradation in the Toxicity Control was 48%. The mean oxygen uptake of the blanks was 17.9 mg O2/L. The pH values were 7.1-7.6 between test initiation and completion.
Table 1. Percent Biodegradation of the Test and Reference Items
Treatment |
Biodegradation at Start of 10-day Window |
Biodegradation at End of 10-day Window*** |
Biodegradation at Day 14* |
Biodegradation at Test Completion (28-d) |
Test 1 |
6% |
N/A |
|
6% |
Test 2 |
14% |
N/A |
|
19% |
Mean |
10% |
N/A |
|
13% |
Reference Item |
|
|
74% |
76% |
Toxicity Control** |
|
|
48% |
50% |
* Validity criteria for Reference Item and Toxicity Control are measured on Day14.
** Calculation of biodegradation in the Toxicity Control is based on the combined ThOD value for the Reference Item and Test Item.
*** Biodegradation at the End of the 10 day window could not be determined as the test ended on day 7 of the 10 day window.
Description of key information
Not readily biodegradable. (OECD TG 301F).
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
- Type of water:
- freshwater
Additional information
At the end of the test, the difference between replicates was 13%. At Day 14 during the study, the biodegradation of the Reference Item was 74% and the percent biodegradation in the Toxicity Control was 48%. The mean oxygen uptake of the blanks was 17.9 mg O2/L. The pH values were 7.1-7.6 between test initiation and completion. All test validity criteria were met. I850 cannot be considered readily biodegradable under the test conditions as I850 did not enter the 10 day window and a result did not surpass 60% biodegradation by the end of the 10-day window. Due to the stringency of this test, test items which do not achieve pass levels may still be biodegradable in the environment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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