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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- June 30, 2017 - August 3, 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Version / remarks:
- Organisation for Economic Co-operation and Development (OECD) Guideline 301D, “301D
Closed Bottle Test” (OECD, 1992) - Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Sebacic acid, compound with 2-aminoethanol (1:2)
- Molecular formula:
- C10H18O4.2(C2H7NO)
- IUPAC Name:
- Sebacic acid, compound with 2-aminoethanol (1:2)
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- An inoculum containing an active microbial population was prepared as follows. Six days prior to
test initiation, a sample of secondary effluent was collected from the Guelph Wastewater
Treatment Plant (Guelph, Ontario). The secondary effluent was continuously aerated during
transport to, and storage at AquaTox, and then pre-conditioned for testing. During preconditioning,
the secondary effluent was maintained at test temperature (22 ± 2 °C) prior to test
initiation. The secondary effluent was settled for 30 minutes prior to the clear supernatant being
decanted for use as the inoculum. - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 3.35 mg/L
- Based on:
- COD
- Remarks:
- 4 mg/L COD
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Remarks:
- D.O. measurement
- Details on study design:
- Sampling done on Days 0, 4, 7, 11, 14, 21 & 28
For each sampling day, the following bottle plan was used:
Non-incoculated control: 1 bottle
inoculated control: 2 bottles
test series: 2 bottles
reference series (procedural control): 2 bottles
inhibition control (toxicity control): 2 bottles
Results and discussion
% Degradation
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 84
- Sampling time:
- 28 d
- Remarks on result:
- other:
- Remarks:
- readily biodegradable
- Details on results:
- The test item achieved 84.0% degradation over the 28-day exposure. Furthermore, based on
visual inspection of the biodegradation curve, the test item achieved approximately 75%
degradation within 10 days after achieving 10% biodegradation (i.e., the 10 day window).
According to the strict requirements of OECD 301D, the test item can be considered to be
readily biodegradable.
BOD5 / COD results
- Results with reference substance:
- The reference substance (KHP) achieved 85% degradation in 14 days. The toxicity control achieved 84.4% degradation in 14 days.
Any other information on results incl. tables
Test day | 0 | 4 | 7 | 11 | 14 | 21 | 28 |
Degradation (%) | 0.0 | 55.0 | 56.2 | 76.2 | 85.0 | 87.5 | 84.0 |
The test item achieved 84% degradation in 28 days. Based on the visual inspection of the biodegradaiton surve, the test item achieved approximately 75% degradation 10 days after achieving 10% degradation .
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The test item, Sebacic acid, compound with 2-aminoethanol achieved 84% degradation in 28 days. All validity criteria were met and the test item can be considered to be readily biodegradable.
- Executive summary:
AquaTox Testing & Consulting Inc. (AquaTox) was retained by the Study Sponsor, Afton
Chemical Corporation, to conduct a study to determine the biodegradability of the test item,
Sebacic Acid MEA Salt (Lot/Batch No. LAB 4408; AquaTox test item number 50508). The study
was conducted in accordance with AquaTox Study Plan 162775728-301 entitled “Sebacic Acid
MEA Salt: Ready Biodegradability Closed Bottle Test (OECD 301D)” (Appendix A) and
AquaTox Standard Operating Procedure (SOP) # 392 (AquaTox, 2016a), which are based on
Organisation for Economic Co-operation and Development (OECD) Guideline 301D, “301D
Closed Bottle Test” (OECD, 1992). The study was conducted in support of global registration.
All components of the study were conducted according to OECD Principles of Good Laboratory
Practice (GLP) (OECD, 1998) with the exception noted in the GLP Compliance Statement.
Testing was initiated on July 6, 2017 and was completed on August 3, 2017. The concentration
of the test item in the mineral medium was 3.35 mg/L. The corresponding Chemical Oxygen
Demand (COD) was 4.0 mg/L. The quality of the test system was confirmed through the use of
a reference substance (potassium hydrogen phthalate, Fisher Scientific, Lot # 034159) and all
of the criteria for test validity were met.
The test item achieved 84.0% degradation over the 28-day exposure. Furthermore, based on
visual inspection of the biodegradation curve, the test item achieved approximately 75%
degradation within 10 days after achieving 10% biodegradation (i.e., the 10 day window).
According to the strict requirements of OECD 301D, the test item can be considered to be
readily biodegradable.
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