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EC number: 203-937-5 | CAS number: 112-12-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- The study was performed between 27 March 2002 and 16 April 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- Data is from study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Undecan-2-one
- EC Number:
- 203-937-5
- EC Name:
- Undecan-2-one
- Cas Number:
- 112-12-9
- Molecular formula:
- C11H22O
- IUPAC Name:
- undecan-2-one
- Test material form:
- liquid
- Remarks:
- clear, colourless
- Details on test material:
- SOURCE OF TEST MATERIAL
- Batch No.of test material: EM97160115
- Expiration date of the lot/batch: 27 January 2018
- Purity test date: 07/07/2016
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- batch No.of test material: 05500109421007
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: room temperature in the dark
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: test material was used as supplied
OTHER SPECIFICS:
- clear colourless liquid
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River (UK) Ltd, Margate, Kent, UK
- Females (if applicable) nulliparous and non-pregnant: yes
- Age at study initiation: eight to twelve weeks
- Weight at study initiation: between 198 and 212 g
- Fasting period before study: overnight
- Housing: 3 per cage (solid-floor polypropylene furnished with woodflakes)
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: five days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 to 25
- Humidity (%): 30 - 70
- Air changes (per hr): 15 changes per hour
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- VEHICLE
The substance was administered undiluted.
MAXIMUM DOSE VOLUME ADMINISTERED: 2000 mg/kg - Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: ½, 1, 2 and 4 hours after dosing and thereafter once daily
for fourteen days.
- Necropsy of survivors performed: yes
- Other examinations performed: signs of toxicity, bodyweights, clinical signs, examination major organs - Statistics:
- An estimation of the acute oral median lethal dose (LD50) of the test material was made by using mortality data.
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
- Based on:
- test mat.
- Mortality:
- One animal was found dead one day after dosing.
- Clinical signs:
- other: other: Signs of systemic toxicity included lethargy, decreased respiratory rate, laboured respiration and ataxia. All animals showed a hunched posture. The surviving animals recovered one or two days after dosing.
- Gross pathology:
- There were no abnormalities recorded for the animals which were sacrificed at the end of the study period. Necropsy on the animal which was found dead one day after dosing showed haemorrhagic lungs, patchy pallor of the liver and dark kidneys.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified Annex I of the CLP Regulation (1272/2008/EC).
- Conclusions:
- The oral median lethal dose (LD50) of Methyl Nonyl Ketone was determined in rats. The LD50 was >2500 mg/kg bw for female rats. Based on these results and according to the EU classification criteria outlined in Annex I of the CLP Regulation (1272/2008/EC) the compound does not need to be classified.
- Executive summary:
Three female rats of the Sprague-Dawley CD strain were treated by oral gavage administration of Methyl Nonyl Ketone (undiluted) at a dose level of 2000 mg/kg bw. This was followed by a second group of three females which were treated with the same dose. The rats were observed for 14 days following dosing after which surviving animals were sacrificed and examined. Mortality and clinical signs were recorded. Signs of systemic toxicity included lethargy, decreased respiratory rate, laboured respiration and ataxia. All animals showed a hunched posture up to the 1st day after exposure. All surviving animals had completely recovered by 48 hours after dosing. One animal was found dead one day after dosing. The Oral Median Lethal Dose (LD50) were determined to be >2500 mg/kg bw. Based on these results and according to the EU classification criteria outlined in Annex I of the CLP Regulation (1272/2008/EC) the compound does not need to be classified.
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