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Diss Factsheets
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EC number: 434-280-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- The study was conducted between February 5, 1985, and April 16, 1985.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Octadec-9-en-1-yl ammonium mono and di-butylphosphate
- Molecular formula:
- C22H48NO4P - C26H56NO4P
- IUPAC Name:
- Octadec-9-en-1-yl ammonium mono and di-butylphosphate
- Reference substance name:
- Octadec-9-en-1-yl ammonium di-n-hexyl phosphorodithioate
- Molecular formula:
- C30H64NO2PS2
- IUPAC Name:
- Octadec-9-en-1-yl ammonium di-n-hexyl phosphorodithioate
- Test material form:
- liquid: viscous
- Details on test material:
- Material is a yellow viscous liquid
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Y oung adult male and female Sprague-DawleyR Crl :coR ( SD) BR rats, supplied by Charles River Breeding Laboratories, Inc. , Wilmington, Massachusetts, were used in this study. Animals dosed in the 5. 0 g/kg screen were received on January 15, 1985, and allowed a conditioning
period of 21 days prior to dosing in our laboratory. Animals used in the LD50 determination arrived January 29, 1985, and were allowed a 42-day conditioning period prior to dosing. An additional dose level was tested in males which were allowed a 56-day conditioning period after arrival on February 5, 1985.
The males were 71 days of age and weighed 299-335 grams, and the females were 78 days of age and weighed 198-223 grams at the time of
dosing the oral screen. The males were 92 days of age and weighed 364-469 grams, and the females were 99 days of age and weighed 197-
257 grams at the time of dosing the LD50. Males in the additional LD5O dose group were 79 days of age and weighed 357-397 grams at the
time of dosing.
The animals were housed individually in wire-bottom cages in an airconditioned room. The temperature ranged from 20.2-24.0°c and the
relative humidity from 31.3-75 .7% during the study. The photoperiod consisted of a 12-hour light/dark cycle: lights on at 0630 and off at 1830. The animals had free access to Purina Laboratory Rodent ChowR 15001 and water except during the overnight period prior to dosing when only water was available.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- The test material was delivered neat; no special preparation was required.
- Doses:
- 1.0, 1.7, 2.9, 3.6 and 5.0 g/kg
(1000, 1700, 2900, 3600 and 5000 mg/kg) - No. of animals per sex per dose:
- 5 males, 5 females per dose group
- Control animals:
- yes
- Details on study design:
- The animals were dosed approximately three to five hours after the onset of the light cycle. They were observed frequently for any physiological or behavioral abnormalities on the day of dosing and at least once each weekday morning and late afternoon for 13 days after treatment; on weekends, the animals were observed once daily. On Day 14, the animals were observed once prior to sacrifice.
Body Weights
The animals were weighed immediately prior to dosing and at 2, 7, and 14 days after treatment with the exception of males dosed on March 12, 1985, which were weighed on Day 3 rather than Day 2. - Statistics:
- The LD50, slope, and 95% confidence limits were determined using the method of Berkson ( 1).
The mean body weights of the treated groups with three or more survivors were compared to those of the respective controls using one-way analysis of variance followed when significant by the least significance difference test (2).
(1) Berkson, J. Tables for use in estimating the normal distribution function by normit analysis. Biometrika, 44: 411-435, 1957.
(2) Sokal, R. R., and Rohlf, F. J. Biometry. Company, San Francisco, pp. 175-252, 1969.
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 3 770 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 780 - 7 200
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 4 570 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 600 - 9 190
- Mortality:
- 5/5 males in the 5000 mg/kg dose group died.
1/5 males in the 3600 mg/kg dose group died.
3/5 females in the 5800 mg/kg dose group died.
4/5 females in the 5000 mg/kg dose group died.
2/5 females in the 3200 mg/kg dose group died. - Clinical signs:
- other: Signs of toxicity observed i n both survivors and animal s that died on study were sal ivation, diarrhea, reduced food intatke/no feces, decreased motor activity, ocular and nasal discharges, lacrimation, anogenital discharge and stain, discolored fur aro
- Gross pathology:
- Gross pathological changes observed at necropsy consisted of thin gastric walls with either enlargement of the stomach or hemorrhage, broken blood vessels, or discoloration of the gastric mucosa in animals dosed with 5 .0 or 5 .8 g/kg of XA 289M. Thickened or blanched intestinal walls, enlarged and darkened adrenal glands, mottled lungs, reddened pancreas, hollow kidneys, and/or alopecia were observed in animals at several dose levels.
Histopathological evaluation showed severe gastric necrosis and ulceration in one male and severe gastric hyperkeratosis in one female. Both animals were dosed at 5.0 g/kg; these lesions may have been compound-related. Other findings of gastritis, congestion of the adrenal glands, lungs, pancreas, and cecum, hydronephrosi s, and acute dermatitis were agonal or related to spontaneous disease.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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