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Diss Factsheets
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EC number: 202-675-9 | CAS number: 98-51-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
SKIN IRRITATION
minimally irritating to the skin (Draize Test; Hine et al., 1954); no labelling required.
EYE IRRITATION
mildly irritating to the eyes (Draize Test; Hine et al., 1954); no labelling required.
Key value for chemical safety assessment
Additional information
SKIN IRRITATION
In a primary dermal irritation study (Hine et al., 1954), p-tertiary-butyltoluene (purity not given) was tested according to the method of Draize et al (Draize Test; no further data).
p-tertiary-Butyltoluene was found to be only a mild rubefacient, with a skin irritation score of less than 0.5, according to the method of Draize. Erythema was more pronounced in the intact than in the scarified areas, and in only 1/6 animals was there evidence of edema at the site of application. No further data.
In this study, p-tertiary-butyltoluene is minimally irritating to the skin based on the Draize scores.
EYE IRRITATION
In a primary eye irritation study (Hine et al., 1954), p-tertiary-butyltoluene(purity not given) was tested according to the method of Draize et al (Draize Test; no further data).
The most consistent sign of eye irritation was a moderate to heavy discharge from the treated eyes. A slight chemosis was evident at the 24-hour point, but it had disappeared before the time of the 48-hour reading. According to Draize's method, the average total scores were 9.3 (1 h), 6.6 (24 h), and 4.0 (72 h) (maximum score = 110). According to the method of Carpenter and Smyth, the grade of irritation was less than 1. According to the authors, these classifications indicate only a moderate irritation of the conjunctivae.
In this study, 4-tertiary-butyltoluene) is mildly irritating to the eye based on the Draize scores.
Justification for classification or non-classification
There is no need to classify 4-tertiary-butyltoluene for skin irritation according to the Directive 67/548/EC or GHS criteria.
There is no need to classify 4-tertiary-butyltoluene for eye irritation according to the Directive 67/548/EC or GHS criteria.
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