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EC number: 274-936-5 | CAS number: 70851-50-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002-05-13 to 2002-07-19
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Guideline study with acceptable restrictions. The study was conducted according to an appropriate OECD test guideline, with acceptable restrictions. The restrictions were that the analytical results showed that measured DOC concentrations were <5% of nominal. As a consequence it has been necessary to reinterpret the results with reference to measured concentrations.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- yes
- Remarks:
- The test media were not prepared in accordance with OECD guidance for testing difficult substances.
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Freie und Hansestadt Hamburg, Behörde für Arbeit, Gesundheit und Soziales, Hamburg, Germany
- Analytical monitoring:
- yes
- Details on sampling:
- - Nominal treatments: 0 (Control), 10.0 and 100 mg/L
- Sampling method: One aliquot from the freshly prepared test media of all test concentrations was taken at the start of the test before filling the test vessels. A combined aliquot was collected from the test media of all 4 replicate test vessels at each concentration at the end of the test.
- Sample storage conditions before analysis: Samples were stored at -20 °C prior to analysis. - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: A stock suspension of the test substance was prepared at a nominal loading rate of 100 mg/L by shaking for 48 hours. The suspension was then filtered through a 0.45 μm cellulose acetate filter. Further treatments were prepared by dilution of the resulting stock solution.
- Controls: yes, dilution water - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Source: IRChA, France
- Age at study initiation: 6-24 hours
- Method of breeding: Laboratory stock culture
- Feeding during test: none
ACCLIMATION
- Acclimation period: at least 1 week
- Acclimation conditions: same as test
- Type and amount of food: log-phase Scenedesmus subspicatus and a small amount of aerated sewage sludge
- Feeding frequency: not reported
- Health during acclimation (any mortality observed): not reported - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 250 mg/L as CaCO3
- Test temperature:
- 20 ± 1°C
- pH:
- 7.33-8.38
- Dissolved oxygen:
- ≥80% ASV
- Salinity:
- not applicable
- Nominal and measured concentrations:
- Nominal treatments: 0 (Control), 10 and 100 mg/L.
The measured concentrations at the start and end of the test were <5% of the theoretical values. The discrepancy is attributed by the report author to the low solubility of the test substance.
The test results are expressed in the test report relative to nominal concentrations (loading rates). The results have been reinterpreted by the reviewer with reference to the measured DOC concentrations and corresponding test substance concentrations. - Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type: open
- Material, size, fill volume: glass, 50 mL with 50 mL of test medium
- Aeration: none
- Renewal rate of test solution: static test
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- Biomass loading rate: 1 daphnid/10 mL
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: reconstituted fresh water
- Alkalinity: 0.8 mmol/L
- Ca/mg ratio: 4:1
- Intervals of water quality measurement: start and end of test
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 hours light, 8 hours dark
- Light intensity: approximately 500 lux
EFFECT PARAMETERS MEASURED: mobility after 24 and 48 hours
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 10
- Range finding study
- Results used to determine the conditions for the definitive study: no data - Reference substance (positive control):
- no
- Duration:
- 48 h
- Dose descriptor:
- EL50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOELR
- Effect conc.:
- 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1.2 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- other: measured DOC concentration; exposure is likely to be to hydrolysis products
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- > 1 - < 1.2 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- other: measured DOC concentration; exposure is likely to be to hydrolysis products
- Basis for effect:
- mobility
- Details on results:
- - Immobilisation of control: 0%
- Any observations that might cause a difference between measured and nominal values: It is speculated in the test report that the lack of agreement between nominal and measured exposure concentrations may be a consequence of the low solubility of the substance and its hydrolysis product. - Reported statistics and error estimates:
- There were insufficient levels of immobilisation to determine a definitive EL50 value. The NOELR has been reassessed by the reviewer in light of the lack of agreement between nominal and measured exposure concentrations. The test results have also been reinterpreted by the reviewer in terms of measured DOC concentrations back-calculated to a corresponding concentration of the test substance and in terms of the expected water solubility of the hydrolysis product.
Reference
Table 1. Test results
Nominal test substance concentration/loading rate (mg/L) | Mean percentage immobilisation after 24 hours | Mean percentage immobilisation after 48 hours |
0 (Control) | 0 | 0 |
10 | 0 | 0 |
100 | 0 | 10 |
Table 2. Results of analysis of test media
Nominal test substance concentration/loading rate (mg/L) | Theoretical DOC concentration (mg/L) | Actual DOC concentration at start of test (mg/L) | Actual DOC concentration at end of test (mg/L) |
10 | 7.0 | <1.0 | <1.0 |
100 | 70.3 | 1.3 | 1.1 |
Description of key information
EL50 (48 h) > 100 mg/L (nominal, OECD 202, Daphnia magna)
Key value for chemical safety assessment
Additional information
One reliable study is available for dimethoxymethyloctadecylsilane (CAS 70851-50-2). The test was performed according to OECD 202 and GLP (2003). Daphnia magna was exposed to nominal concentrations of 0 (control), 10 mg/L and 100 mg/L for 48 h. The test item solution was prepared by mixing 100 mg test item/L, shaking for 48 h and filtering through a 0.45 µm filter. The test item concentrations were monitored by DOC measurements during the test. However, measured values ranged between 1.3 mg/L and below the detection limit. Due to rapid hydrolysis of the substance in aqueous environments (2.6 h at 20 °C), it is very likely that the test organisms were exposed to the hydrolysis products of the test substance. The study resulted in an EL50 (48 h) of > 100 mg/L (nominal). Based on these results dimethoxymethyloctadecylsilane is not assumed to cause harmful short-term effects to aquatic invertebrates.
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