Registration Dossier
Registration Dossier
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EC number: 270-472-2 | CAS number: 68441-68-9
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
No effects up to the limit concentration (OECD 209); read-across
Key value for chemical safety assessment
Additional information
There is no study available investigating the toxicity of Tetraesters of 2,2-bis(hydroxymethyl)propane-1,3-diol and decanoic and octanoic acid (CAS 68441-68-9) to aquatic microorganisms. Therefore, read-across to the structurally related source substance Decanoic acid, mixed esters with heptanoic acid, octanoic acid, pentaerythritol and valeric acid (CAS 71010-76-9) was conducted in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5. Based on the high degree of similarity between the structural and physico-chemical properties of the target and source substances, the source substances are considered suitable representatives for the assessment of the toxicity of the target substance to microorganisms. The read-across approach is justified in detail within the analogue justification in IUCLID section 13.
The available study was conducted according to OECD 209 and GLP. In a static test, 10, 100 and 1000 mg/L test item were inoculated with non-adapted activated sludge obtained from a domestic sewage treatment plant for 3 h under static conditions. Test substance was added directly to the test vessels. The test substance did not inhibit the respiration rate of activated sludge microorganisms at any of the concentrations employed in the test and resulted in a EC50 (3 h) of > 1000 mg/L based on the nominal test concentration. Thus, no effects up to the limit of water solubility (< 0.05 mg/L) were observed.
Based on the available result from the structurally related source substance (in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5), it can be concluded that Tetraesters of 2,2-bis(hydroxymethyl)propane-1,3-diol and decanoic and octanoic acid (CAS 68441-68-9) will not exhibit toxic effects on microorganisms up to the limit of water solubility.
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