Fluorine

Long-term toxicity to fish

Administrative data

Endpoint:

adult fish: sub(lethal) effects

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

Available ecotoxicity data on (hydrogen) fluoride up to 1998 was reviewed and summarised by the European Chemicals Bureau (ECB). Although detail on design and methodology is very limited in this report, endpoints and conclusions are considered suitably reliable for environmental risk assessment as the substance was assessed as part of the EU-RAR and in accordance with Council Regulation (EEC) 793/93 on the evaluation and control of risks of existing substances.

Data source

Reference

Reference Type:

publication

Title:

European Union Risk Assessment Report - Hydrogen Fluoride

Author:

Institute for Health and Consumer Protection, European Chemicals Bureau

Year:

2001

Bibliographic source:

European Chemicals Bureau Existing Substances, 1st priority list, no. 8

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

A 21-day fish toxicity study is mentioned. Details on design and methodology are however not provided.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Sodium fluoride

EC Number:

231-667-8

EC Name:

Sodium fluoride

Cas Number:

7681-49-4

Molecular formula:

FNa

IUPAC Name:

sodium fluoride

Test material form:

not specified

Details on test material:

In the EU-RAR it is stated that all reported tests with aquatic organisms were performed with NaF and that results were corrected for the fluoride ion.

Sampling and analysis

Analytical monitoring:

not specified

Test solutions

Vehicle:

no

Details on test solutions:

No

Test organisms

Test organisms (species):

Oncorhynchus mykiss (previous name: Salmo gairdneri)

Study design

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

21 d

Test conditions

Hardness:

soft water (12 mg CaCO3/l)

Nominal and measured concentrations:

The effect value given is based on the actual concentration.

Reference substance (positive control):

no

Results and discussion

Effect concentrations

Duration:

21 d

Dose descriptor:

NOEC

Effect conc.:

4 mg/L

Nominal / measured:

meas. (not specified)

Conc. based on:

other: fluoride ion (F-)

Basis for effect:

mortality

Details on results:

In a 21 day test with Oncorhynchus mykiss a LC5 value of 4 mg/L was reported (actual concentration). This value is considered to be equivalent to the NOEC for mortality. The test was conducted in very soft (12 mg CaCO3/L) natural water with daily renewal of the test water.

Applicant's summary and conclusion

Validity criteria fulfilled:

not specified

Conclusions:

The 21-d LC5 value (equivalent to the NOEC) is 4 mg/L in Oncorhynchus mykiss.

Executive summary:

In a 21 day test with Oncorhynchus mykiss a LC5 value of 4 mg/L was reported (actual concentration). This value is considered to be equivalent to the NOEC for mortality. The test was conducted in very soft (12 mg CaCO3/L) natural water with daily renewal of the test water.