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EC number: 821-997-6 | CAS number: 2136366-99-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March - April 2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- 2001
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- reaction products of 2-Propenoic acid (2 moles) and Neopentylglycol hydroxypivalate (1 mole)
- EC Number:
- 821-997-6
- Cas Number:
- 2136366-99-7
- Molecular formula:
- C11H16O6 to C21H32O8
- IUPAC Name:
- reaction products of 2-Propenoic acid (2 moles) and Neopentylglycol hydroxypivalate (1 mole)
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Orient Bio Co., Ltd, korea
- Age at study initiation: 8/9 weeks old
- Weight at study initiation: 201.1-218.1 g
- Fasting period before study: yes
- Housing: by 3
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21.6-22.2
- Humidity (%): 47.1-52.6
- Air changes (per hr): 10-15
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- For 2000 mg/kg bw treatment to the animals, the test substance suspended with autoclaved distilled water to bring the formulation to 200 mg/mL test substance.
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 6 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical signs were carefully observed for 4 hours after treatment and then an once every day for 14 days. Bodyweight was measured animal receipt day, animal allocation day, just before treatment and on day 7 and 14 after the administration
- Necropsy of survivors performed: yes, on the end of study period, all animals were examined for external findings. - Statistics:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD0
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- No mortality was observed.
- Clinical signs:
- other: Clinical signs related with the test substance in all animals were not observed during the observation period.
- Gross pathology:
- In all animals, there were no lesions caused by administration of the test substance.
- Other findings:
- no
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on these results, there were no mortality when the test substance was acute administrated orally at a dose volume of 2000 mg/kg bw in female rats, the oral LD50 is higher than 2000 mg/kg bw.
- Executive summary:
The acute oral toxicity study was conducted to the SD rats. The test substance was administrated only one time by oral route at a dose volume of 2000 mg/kg bw. Three animals were used for each step that divided 1 step and 2 step. Mortality, clinical signs, body weights and necropsy findings were observed for 14 days. No mortality was observed. Clinical signs related with the test substance in all animals were not observed during the observation period. All tested animals showed normal gains in body weights. In all animals, there were no lesions caused by administration of the test substance. Based on these results, there were no mortality when the test substance was acute administrated orally at a dose volume of 2000 mg/kg bw in female rats, the oral LD50 is higher than 2000 mg/kg bw.
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