Potassium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulphonate

Health surveillance data

Administrative data

Endpoint:

health surveillance data

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

2006

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

publication

Title:

Perfluorooctanesulfonate and related fluorochemicals in human blood samples from China

Author:

Yeung, L.W.Y.; So, M.K.; Jiang, G.; Taniyasu, S.; Yamashita, N.; Song, M.; Wu, Y.; Li, J.; Giesy, J.P.; Guruge, K.S.; Lam, P.K.S.

Year:

2006

Bibliographic source:

Environmental Science and Technology. 40: 715-720.

Materials and methods

Study type:

biological exposure monitoring

Endpoint addressed:

other: Background PFBS levels in whole blood samples taken from volunteers in various Chinese provinces.

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

- Principle of test: Samples of whole human blood were collected from volunteer donors (n=85) from local universities or hospitals in China in 2004 (Jiangsu, Zhejiang, Liaoning, Guizhou, Hubei, Hebei, Fujian, and Henan provinces). The donors ranged in age from 7-66 years old.

- Short description of test conditions: Whole blood samples were stored in polypropylene (PP) containers or vacutainers at -20 °C until analysis.

- Parameters analysed / observed: Presence of PFBS was determined using a high-performance liquid chromatograph-tandem mass spectrometer (HPLC-MS/MS) with a limit of quantification (LOQ) or 100 pg/mL.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Potassium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulphonate

EC Number:

249-616-3

EC Name:

Potassium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulphonate

Cas Number:

29420-49-3

Molecular formula:

C4HF9O3S.K

IUPAC Name:

potassium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
Incidental environmental exposure to PFBS.

The standard for analytical method development was sourced from 3M Company.

Method

Type of population:

general

Ethical approval:

not specified

Details on study design:

See 'Principles of Method' section.

Results and discussion

Results:

PFBS was not detected in any samples as all the samples were below the limit of quantitation.

Applicant's summary and conclusion

Conclusions:

PFBS was not detected in any samples as all the samples were below the limit of quantitation.

Executive summary:

Samples of whole human blood were collected from volunteer donors (n=85) from local universities or hospitals in China in 2004 (Jiangsu, Zhejiang, Liaoning, Guizhou, Hubei, Hebei, Fujian, and Henan provinces). The donors ranged in age from 7-66 years old. Whole blood samples were stored in polypropylene (PP) containers or vacutainers at -20 °C until analysis. The presence of PFBS was determined using a high-performance liquid chromatograph-tandem mass spectrometer (HPLC-MS/MS) with a limit of quantification (LOQ) or 100 pg/mL. PFBS was not detected in any samples as all the samples were below the limit of quantitation.