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EC number: 946-992-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14 February 2017 to 22 February 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Key result
- Water solubility:
- 0.34 g/L
- Conc. based on:
- test mat.
- Incubation duration:
- 5 d
- Temp.:
- 20 °C
- pH:
- 3
- Details on results:
- DEFINITIVE TEST RESULTS
Samples were taken from the three flasks at two time points: Day 4 and Day 5. Table 1 summarises the analytical measurements from the experiment. The between day difference between Day 4 and 5 was less than 15 %. No other sampling was required. The amount of test material dissolved in water was 0.34 g/L. The test temperature ranged from 19.6 to 20.3 °C (20.0 ± 0.35 °C).
OBSERVATIONS
No chemical instability was observed during the test. It was noted during method development that increasing amounts of un-dissolved test material in water led to increasing apparent solubility of the test material. The test material is a UVCB; therefore the increasing amount of material found in the water during method development may be due to preferentially soluble components in the test material or impurities. - Conclusions:
- Under the conditions of this study the test material had a water solubility of 0.34 g/L at 20.0 °C.
- Executive summary:
The water solubility of the test material was determined in accordance with the standardised guideline OECD 105 under GLP conditions using the flask method.
A preliminary test was conducted in order to approximate the amount of test material that would dissolve in water and the time required to reach saturation. There was un-dissolved test material visible on the surface of the water in the preliminary test flask when observed after shaking overnight. Therefore the preliminary test indicated a water solubility of less than 1 g/L.
The flask method was used for determination of solubility. Based on the preliminary test results, three containers with lids were prepared containing 0.1 g of the test material in 100 mL of water. Flasks were placed in a water bath at 20.0 ± 0.5 °C with constant orbital shaking at 150 rpm until equilibrium was reached. Equilibrium was determined by either the observation that no un-dissolved test material remained, or, by two consecutive daily measurements of the dissolved test material being within 15 % of each other. An aliquot from each flask was collected after Day 4 and 5 for analysis. The between day difference between Day 4 and 5 was less than 15 % so no other sampling was required.
Under the conditions of this study the test material had a water solubility of 0.34 g/L at 20.0 °C.
Reference
Table 1: Results summary
Sample |
Day 4 (g/L)
|
pH |
Day 5 (g/L)
|
pH |
Sample 1 |
0.33 |
3 |
0.34 |
3 |
Sample 2 |
0.34 |
3 |
0.36 |
3 |
Sample 3 |
0.34 |
3 |
0.35 |
3 |
Time point’s average test material concentration |
0.34 |
|
0.35 |
|
Within day RSD (%) |
1.7 |
2.8 |
||
Between day average test material concentration (g/L) |
0.34 |
|||
Between day difference (%) |
2.6 |
RSD = Relative Standard Deviation
Description of key information
Under the conditions of this study the test material had a water solubility of 0.34 g/L at 20.0 °C.
Key value for chemical safety assessment
- Water solubility:
- 0.34 g/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test material was determined in accordance with the standardised guideline OECD 105 under GLP conditions using the flask method. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).
A preliminary test was conducted in order to approximate the amount of test material that would dissolve in water and the time required to reach saturation. There was un-dissolved test material visible on the surface of the water in the preliminary test flask when observed after shaking overnight. Therefore the preliminary test indicated a water solubility of less than 1 g/L.
The flask method was used for determination of solubility. Based on the preliminary test results, three containers with lids were prepared containing 0.1 g of the test material in 100 mL of water. Flasks were placed in a water bath at 20.0 ± 0.5 °C with constant orbital shaking at 150 rpm until equilibrium was reached. Equilibrium was determined by either the observation that no un-dissolved test material remained, or, by two consecutive daily measurements of the dissolved test material being within 15 % of each other. An aliquot from each flask was collected after Day 4 and 5 for analysis. The between day difference between Day 4 and 5 was less than 15 % so no other sampling was required.
Under the conditions of this study the test material had a water solubility of 0.34 g/L at 20.0 °C.
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