Bismuth chloride oxide

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1974

Report date:

1974

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: Federal Hazardous Substances Act

Principles of method if other than guideline:

- Principle of test: Draize Test

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Bismuth chloride oxide

EC Number:

232-122-7

EC Name:

Bismuth chloride oxide

Cas Number:

7787-59-9

Molecular formula:

BiClO

IUPAC Name:

chlorobismuthanone

Test material form:

solid

Test animals

Species:

rabbit

Strain:

New Zealand White

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Dutchland Laboratory Animals, Inc., Denver, Pennsylvania, USA

Test system

Type of coverage:

occlusive

Preparation of test site:

other: clipped intact or abraded

Vehicle:

water

Controls:

no

Amount / concentration applied:

TEST MATERIAL
- Amount applied: 0.5 mL
- Concentration: 50%

Duration of treatment / exposure:

24 hours

Observation period:

72 hours

Number of animals:

6 (per intact and abraded skin)

Details on study design:

TEST SITE
- Area of exposure: On the back, (intact and abraded skin sites)
- Coverage square: One inch
- Type of wrap: Gauze patches

OBSERVATION TIME POINTS: 24 and 72 hours

SCORING SYSTEM:
- Method of calculation: J.H. Draize, Appraisal of the Safety of Chemicals in Foods, Drugs, and Cosmetics, Assoc. Food and Drug Officials of the U.S., Austin, Texas, 1959

Evaluation of Skin Reactions

Erythema and eschar formation:
No erythema: 0
Very slight erythema (barely perceptible): 1
Well-defined erythema: 2
Moderate to severe erythema: 3
Severe erythema (beet redness) to slight eschar formation (injuries in depth): 4

Edema formation:
No edema: 0
Very slight edema (barely perceptible): 1
Slight edema (edges of area well defined by definite raising): 2
Moderate edema (raised approximately 1.0 mm.): 3
Severe edema (raised more than 1.0 mm. extending beyond the area of exposure): 4

The values-for erythema and eschar formation at 24 hours-and 72 hours for intact skin animals will be added to the values on abraded skin animals at 24 and 72 hours (four values). Similarly, the values for edema formation at 24 hours and at 72 hours for the intact and abraded skin animals will be added (four values). The primary irritant score is the total of the eight values divided by four. A primary irritant is one which results in a score of five or more as tested by this method.

Results and discussion

In vivo

Results

Irritation parameter:

primary dermal irritation index (PDII)

Basis:

mean

Time point:

other: 24 and 72 hours

Score:

0

Max. score:

8

Any other information on results incl. tables

The skin irritation study was conducted according to the Federal Hazardous Substances Act.

0.5 mL of the test substance (formulation of 50% in water) was administered to six rabbits on the intact and abraded skin for 24 hours. At 24 and 72 hours observations were made, graded, and scored according to the system of J. H. Draize.

The primary irritation score for the test substancel was 0.0; therefore, the test substance is not a primary irritant under the conditions of this test.

Applicant's summary and conclusion

Interpretation of results:

other: CLP/ EU GHS criteria not met, no classification required according to Regulation (EC) No 1272/2008

Conclusions:

CLP: not classified