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EC number: 217-552-5 | CAS number: 1885-38-7
Endpoint summary
Administrative data
Description of key information
Biodegradation in water:
Biodegradability of test chemical (E)-3-phenylprop-2-enenitrile (CASno.1885-38-7) was predicted by using OECD QSAR tool box v3.3 with log Kow as primary descriptor. The test chemical (E)-3-phenylprop-2-enenitrile showed 1.1857 % biodegradation by considering BOD parameter and Microorganisms as inoculum in 28 days. Based on percent biodegradability value it is concluded that this test chemical is not readily biodegradable.
Biodegradation in water and sediments:
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound (E)-3-phenylprop-2-enenitrile (CAS No. 1885 -38 -7). If released in to the environment, 25.2 % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is low whereas the half-life period of test chemical (E)-3-phenylprop-2-enenitrile in sediment is estimated to be135 days (3240 hrs). However, as the percentage release of test chemical into the sediment is less than 1 % (i.e, reported as 0.344 %), indicates that test chemical (E)-3-phenylprop-2-enenitrile is not persistent in sediment.
Biodegradation in soil:
The half-life period of test chemical (E)-3-phenylprop-2-enenitrile (CAS No. 1885-38-7) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 72.7% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical (E)-3-phenylprop-2-enenitrile in soil is estimated to be 30 days (720 hrs). Based on this half-life value of test chemical (E)-3-phenylprop-2-enenitrile, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is low
Additional information
Biodegradation in water:
Predicted data for the target compound (E)-3-phenylprop-2-enenitrile (CAS no.1885-38-7)and supporting weight of evidence studies for its read across substance were reviewed for the biodegradation end point which is summarized as below:
In first weight of evidence study biodegradability of test chemical (E)-3-phenylprop-2-enenitrile (CASno.1885-38-7) was predicted by using OECD QSAR tool box v3.3 with log Kow as primary descriptor. The test chemical (E)-3-phenylprop-2-enenitrile showed 1.1857 % biodegradation by considering BOD parameter and Microorganisms as inoculums in 28 days. Based on percent biodegradability value it is concluded that this test chemical is not readily biodegradable.
Another prediction was done by using Estimation Programs Interface Suite (EPI suite, 2017) to estimate biodegradation potential of the test compound(E)-3-phenylprop-2-enenitrile (CAS no. 1885-38-7) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical (E)-3-phenylprop-2-enenitrileis expected to be not readily biodegradable.
In supporting weight of evidence study Biodegradation experiment was carried out according to OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I)) for evaluating the percentage biodegradability of read across substance (2-bromovinyl)benzene (CAS no. 103-64-0) from Eisei Kagaku journal (1988). Initial test substance conc. used in the study was 20 mg/L. A water, acetone or DMSO solution (0.1 ml) of the read across chemical was added to a mixture of river/sea water (4.9 ml) from an unpolluted area and an autoclaved solution (5.0ml) of 0.2% peptone in a sterile test tube with a tight plug. After sealed with film and fixed at an angle of 30°in a dark box, the test tubes were incubated at 30°C and shaked at 120rpm. Inoculum used for the study was mixed culture obtained from different sources (Sea water from Enoshima Beach and River water from Tama River).The percentage degradation of test substance in both river and sea water was determined to be 5 and 6% by BOD parameter in 3 days. Thus, based on percentage degradation, read across chemical (2-bromovinyl)benzene is considered to be not readily biodegradable in nature.
Another weight of evidence study done from authoritative database ( Jcheck, 2017) for read across chemical (2 -bromovinyl)benzene (CAS no.103-62-4). In this study Biodegradation experiment was conducted for 28 days for evaluating the percentage biodegradability of read across substance (2 -bromovinyl)benzene (CAS no. 103-62-4). Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l. The percentage degradation of read across substance was determined to be 0 and 4% degradation by BOD and GC parameter in 28 days. Thus, based on percentage degradation, read across chemical (2 -bromovinyl)benzene is considered to be not readily biodegradable in nature.
On the basis of results of above mentioned studies for target chemical (E)-3-phenylprop-2-enenitrile (CAS no.1885-38-7) (from OECD QSAR tool box v3.3 and EPI suite) and supporting weight of evidence study. It is concluded that the test chemical (E)-3-phenylprop-2-enenitrile can be expected to be not readily biodegradable.
Biodegradation in water and sediments:
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound (E)-3-phenylprop-2-enenitrile (CAS No. 1885 -38 -7). If released in to the environment, 25.2 % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is low whereas the half-life period of test chemical (E)-3-phenylprop-2-enenitrile in sediment is estimated to be135 days (3240 hrs). However, as the percentage release of test chemical into the sediment is less than 1 % (i.e, reported as 0.344 %), indicates that test chemical (E)-3-phenylprop-2-enenitrile is not persistent in sediment.
Biodegradation in soil:
The half-life period of test chemical (E)-3-phenylprop-2-enenitrile (CAS No. 1885-38-7) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 72.7% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical (E)-3-phenylprop-2-enenitrile in soil is estimated to be 30 days (720 hrs). Based on this half-life value of test chemical (E)-3-phenylprop-2-enenitrile, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is low
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